1283089-20-2Relevant academic research and scientific papers
Development of methods for the synthesis of libraries of substituted maleimides and α,β-unsaturated-γ-butyrolactams
Awuah, Emelia,Capretta, Alfredo
, p. 3122 - 3130 (2011/06/24)
Synthetic methods for the preparation of maleimide and α,β- unsaturated-γ-butyrolactam compound collections are described. These routes take advantage of Pd cross-coupling and conjugate addition/elimination reactions to permit the facile production of bisaryl-maleimides, anilinoaryl-maleimides, and bisanilino-maleimides while allowing control over the synthesis of symmetrical or nonsymmetrical derivatives. Similarly, the chemistry developed allows for the generation of bisaryl substituted α,β-unsaturated-γ-butyrolactams. The scope and limitations of the approaches are presented.
