1283594-63-7

Basic information

• Product Name: N,N'-dimethyl-N,N'-(methylenedi-4,1-phenylene)bis[2-(1-pyrrolidinyl)acetamide]
• Synonyms: N,N'-dimethyl-N,N'-(methylenedi-4,1-phenylene)bis[2-(1-pyrrolidinyl)acetamide]
• CAS NO: 1283594-63-7
• Molecular Weight: 448.608
• Mol File: 1283594-63-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N,N'-dimethyl-N,N'-(methylenedi-4,1-phenylene)bis[2-(1-pyrrolidinyl)acetamide](CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-dimethyl-N,N'-(methylenedi-4,1-phenylene)bis[2-(1-pyrrolidinyl)acetamide](1283594-63-7)
• EPA Substance Registry System: N,N'-dimethyl-N,N'-(methylenedi-4,1-phenylene)bis[2-(1-pyrrolidinyl)acetamide](1283594-63-7)

Safety Data

• Hazardous Substances Data: 1283594-63-7(Hazardous Substances Data)

Upstream product

• 101-77-9 4,4'-diamino diphenyl methane 
• 52721-83-2 N,N'-(methylenebis(4,1-phenylene))diformamide 
• 1807-55-2 4,4'-methylenebis(N-methylaniline) 
• 123-75-1 pyrrolidine 
• 1283594-61-5 N,N'-dimethyl-N,N'-(methylenedi-4,1-phenylene)bis(2-bromoacetamide) 

Relevant articles and documents

Synthesis of GN8 derivatives and evaluation of their antiprion activity in TSE-infected cells

A series of GN8 derivatives were synthesized from various diamines, carboxylic acid derivatives, and nitrogen nucleophiles, and their antiprion activity was tested in TSE-infected mouse neuronal cells. We found that two ethylenediamine units, hydrophobic substituents on the nitrogen atoms, and the diphenylmethane scaffold were essential structural features responsible for the activity. Seven derivatives bearing substituents at the benzylic position exhibited an improved antiprion activity with the IC50 values of 0.51-0.83 μM. Conformational analysis of model compounds suggested that the introduction of the substituent at the benzylic position restricted the conformational variability of the diphenylmethane unit.