1283598-27-5Relevant academic research and scientific papers
N-alkylation of unsymmetrical 1,6-dihydro-1,2,4,5-tetrazine under alkali condition
Xu, Feng,Yang, Zhen-Zhen,Zhang, Shi-Jie,Hu, Wei-Xiao
scheme or table, p. 3367 - 3375 (2011/09/16)
6-Methyl-3-phenyl-1,6-dihydro-1,2,4,5-tetrazine was stable in alkali solution at room temperature and decomposed gradually to form 1,2-dibenzylidenehydrazine. The plausible mechanism of the reaction is discussed. Because it was stable for a period of time, a convenient and effective method for synthesis of 1-alkyl-1,6-dihydro-1,2,4,5-tetrazines has been developed. The starting 1,6-dihydro-1,2,4,5-tetrazine can be alkylated with alkyl halides in methanol and lithium hydroxide monohydrate as a base at room temperature.
