1283635-94-8Relevant academic research and scientific papers
Catalytic asymmetric ring-opening of meso- aziridines with malonates under heterodinuclear rare earth metal Schiff base catalysis
Xu, Yingjie,Lin, Luqing,Kanai, Motomu,Matsunaga, Shigeki,Shibasaki, Masakatsu
, p. 5791 - 5793 (2011)
Catalytic asymmetric ring-opening of meso-aziridines with malonates is described. The combined use of two rare earth metal sources with different properties promoted the desired ring-opening reaction. A 1:1:1 mixture of a heterobimetallic La(O-iPr)3/Yb(OTf)3/Schiff base 1a (0.25-10 mol %) efficiently promoted the reaction of five-, six-, and seven-membered ring cyclic meso-aziridines as well as acyclic meso-aziridines with dimethyl, diethyl, and dibenzyl malonates, giving chiral cyclic and acyclic γ-amino esters in 99-63% yield and >99.5-97% ee.
