1283668-82-5Relevant academic research and scientific papers
NHC-catalyzed oxidative cyclization reactions of 2-alkynylbenzaldehydes under aerobic conditions: Synthesis of O-Heterocycles
Park, Jong Hyub,Bhilare, Sachin V.,Youn, So Won
, p. 2228 - 2231 (2011/07/09)
Chemical equations presented. An NHC-catalyzed, regio- and stereoselective oxidative cyclization of o-alkynylbenzaldehydes bearing an unactivated alkyne moiety as an internal electrophile has been developed to afford phthalides and isocoumarins. A single organocatalytic system enabled two sequential C-O bond formations to take place in an atom economical manner via highly efficient dual activation. Molecular oxygen in air could be utilized as a source of an oxygen atom for the oxidation of aldehydes to the corresponding benzoic acids under our newly developed reagent system.
Direct synthesis of highly fused perimidines by copper(I)-catalyzed hydroamination of 2-ethynylbenzaldehydes
Tokimizu, Yusuke,Ohta, Yusuke,Chiba, Hiroaki,Oishi, Shinya,Fujii, Nobutaka,Ohno, Hiroaki
experimental part, p. 5168 - 5175 (2011/07/31)
A novel synthesis of highly fused perimidine derivatives was achieved in two steps from 2-alkynylbenzaldehydes. Copper-catalyzed annulation of 2-[(2-bromophenyl)ethynyl]benzaldehydes with 1,8-diaminonaphthalene produced dihydroisoquinolino[2,1-a]perimidines bearing a 2-bromophenyl group. Subsequent palladium-catalyzed C-H arylation provided dibenzo[1,2:7,8]quinolizino[3,4,5,6- kla]perimidine derivatives in moderate to good yields.
