128368-59-2

Upstream product

• 128368-58-1 (3aS,4R,6aR)-4-((R)-2-Cyano-1-hydroxy-ethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid benzyl ester 
• 7115-24-4 (R)-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]((4R,5R)-2,2-dimethyl-5-{[(methylsulfonyl)oxy]methyl}-1,3-dioxolan-4-yl)methyl methanesulfonate 
• 128368-57-0 (R)-3-((3aS,4R,6aR)-2,2-Dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-4-yl)-3-hydroxy-propionitrile 
• 128442-43-3 4,5-anhydro-1-azido-1-deoxy-2,3-O-isopropylidene-D-talitol 
• 128368-55-8 [(2R,3S)-3-((4R,5R)-5-Azidomethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-oxiranyl]-acetonitrile 
• 128442-45-5 1-azido-1-deoxy-2,3-O-isopropylidene-4-O-methanesulphonyl-D-mannitol 
• 128442-44-4 Methanesulfonic acid (R)-((4R,5R)-5-azidomethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl ester 

Downstream Products

• 128368-60-5 (3aS,4S,6aR)-4-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-carbamoyl-ethyl]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

SYNTHESIS OF THE MANNOSIDASE INHIBITORS SWAINSONINE AND 1,4-DIDEOXY-1,4-IMINO-D-MANNITOL AND OF THE RING CONTRACTED SWAINSONINES, (1S, 2R, 7R, 7aR)-1,2,7-TRIHYDROXYPYRROLIZIDINE AND (1S, 2R, 7S, 7aR)-1,2,7-TRIHYDROXYPYRROLIZIDINE.

4,5-Anhydro-1-azido-1-deoxy-2,3-O-isopropylidene-D-talitol is a divergent intermediate for the efficient and practical syntheses of 1,4-dideoxy-1,4-imino-D-mannitol, swainsonine and of the ring contracted swainsonines, (1S, 2R, 7R, 7aR)-1,2,7-trihydroxypyrrolizidine and (1S, 2R, 7S, 7aR)-1,2,7-trihydroxypyrrolizidine.The effect on glycosidases of the ring contracted swainsonines is reported.