7115-24-4

Basic information

• Product Name: METHANESULFONIC ACID (4S,5S)-5-[(S)-((R)-2,2-DIMETHYL-[1,3]DIOXOLAN-4-YL)-METHANESULFONYLOXY-METHYL]-2,2-DIMETHYL-[1,3]DIOXOLAN-4-YLMETHYL ESTER
• Synonyms: METHANESULFONIC ACID (4S,5S)-5-[(S)-((R)-2,2-DIMETHYL-[1,3]DIOXOLAN-4-YL)-METHANESULFONYLOXY-METHYL]-2,2-DIMETHYL-[1,3]DIOXOLAN-4-YLMETHYL ESTER
• CAS NO: 7115-24-4
• Molecular Formula: C₁₄H₂₆O₁₀S₂
• Molecular Weight: 418.48024
• Mol File: 7115-24-4.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: METHANESULFONIC ACID (4S,5S)-5-[(S)-((R)-2,2-DIMETHYL-[1,3]DIOXOLAN-4-YL)-METHANESULFONYLOXY-METHYL]-2,2-DIMETHYL-[1,3]DIOXOLAN-4-YLMETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: METHANESULFONIC ACID (4S,5S)-5-[(S)-((R)-2,2-DIMETHYL-[1,3]DIOXOLAN-4-YL)-METHANESULFONYLOXY-METHYL]-2,2-DIMETHYL-[1,3]DIOXOLAN-4-YLMETHYL ESTER(7115-24-4)
• EPA Substance Registry System: METHANESULFONIC ACID (4S,5S)-5-[(S)-((R)-2,2-DIMETHYL-[1,3]DIOXOLAN-4-YL)-METHANESULFONYLOXY-METHYL]-2,2-DIMETHYL-[1,3]DIOXOLAN-4-YLMETHYL ESTER(7115-24-4)

Safety Data

• Hazardous Substances Data: 7115-24-4(Hazardous Substances Data)

Upstream product

• 7757-38-2 2,3,5,6-di-O-isopropylidene-D-mannofuranose 
• 124-63-0 methanesulfonyl chloride 
• 14131-84-1 2,3:5,6-di-O-isopropylidene-α-D-mannofuranose 
• 78964-16-6 2,3;5,6-di-O-isopropylidene-β-D-mannofuranose 
• 77-76-9 2,2-dimethoxy-propane 
• 357604-61-6 2,3:4,6-di-O-isopropylidene-D-mannopyranose 
• 530-26-7 D-Mannose 
• 40036-82-6 [2,3:5,6]-di-O-isopropylidene-D-mannose 
• 3458-28-4 D-Mannose 
• 38145-92-5 4,5-mono-O-isopropylidene-D-mannitol 
• 3969-61-7 2,3,5,6-di-isopropyIidene-1,4-dihydroxy-D-mannitol 

Downstream Products

• 117781-06-3 (S)-1-((3aS,4S,6aR)-5-benzyl-2,2-dimethyltetrahydro-4H-[1,3] dioxolo[4,5-c]pyrrol-4-yl)ethane-1,2-diol 
• 117781-07-4 N-benzyl-1,4-dideoxy-1,4-imino-D-talitol 
• 117858-82-9 (2S,3S,4R)-N-benzyl-2-hydroxymethyl-3,4-O-isopropylidenepyrrolidine-3,4-diol 
• 115509-95-0 (2S,3S,4R,1'S)-3,4-dihydroxy-2-1',2'-dihydroxyethylpyrrolidine 
• 128368-60-5 (3aS,4S,6aR)-4-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-carbamoyl-ethyl]-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid benzyl ester 
• 128368-59-2 (3aS,4R,6aR)-4-((R)-2-Carbamoyl-1-hydroxy-ethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid benzyl ester 
• 128368-58-1 (3aS,4R,6aR)-4-((R)-2-Cyano-1-hydroxy-ethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid benzyl ester 
• 95189-02-9 1,4-dideoxy-1,4-imino-D-mannitol 
• 72741-87-8 swainsonine 
• 117770-02-2 (3aS,4S,6aR)-5-benzyl-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyrrole 

Relevant articles and documents

Synthesis and antioxidant capacity of novel stable 5-tellurofuranose derivatives

Novel stable tellurium-containing carbohydrate derivatives are prepared from hexitols and pentitols through a double nucleophilic substitution with NaHTe in PEG-400. These tellurosugars react at very high rates with two-electron oxidants, including hypochlorous and peroxynitrous acid, formed at sites of inflammation, and show considerable promise as protective agents against oxidative damage.

Discovery and Structure-Activity Relationships of Novel Template, Truncated 1′-Homologated Adenosine Derivatives as Pure Dual PPARγ/δModulators

Following our report that A3 adenosine receptor (AR) antagonist 1 exhibited a polypharmacological profile as a dual modulator of peroxisome proliferator-activated receptor (PPAR)γ/δ, we discovered a new template, 1′-homologated adenosine analogues 4a-4t, as dual PPARγ/δmodulators without AR binding. Removal of binding affinity to A3AR was achieved by 1′-homologation, and PPARγ/δdual modulation was derived from the structural similarity between the target nucleosides and PPAR modulator drug, rosiglitazone. All the final nucleosides were devoid of AR-binding affinity and exhibited high binding affinities to PPARγ/δbut lacked PPARα binding. 2-Cl derivatives exhibited dual receptor-binding affinity to PPARγ/δ, which was absent for the corresponding 2-H derivatives. 2-Propynyl substitution prevented PPARδ-binding affinity but preserved PPARγaffinity, indicating that the C2 position defines a pharmacophore for selective PPARγligand designs. PPARγ/δdual modulators functioning as both PPARγpartial agonists and PPARδantagonists promoted adiponectin production, suggesting their therapeutic potential against hypoadiponectinemia-associated cancer and metabolic diseases.

Correlation study between A3 adenosine receptor binding affinity and anti-renal interstitial fibrosis activity of truncated adenosine derivatives

Truncated 4′-thionucleosides 1–4 and 4′-oxonucleosides 5–8 as potent and selective A3AR antagonists were synthesized from d-mannose and d-erythronic acid γ-lactone, respectively. These nucleosides were evaluated for their anti-fibrotic renoprot