128373-93-3Relevant academic research and scientific papers
Synthesis and anti-hyperglycemic activity of hesperidin derivatives
Zhang, Baoshun,Chen, Tingting,Chen, Zhu,Wang, Mingxue,Zheng, Dengyu,Wu, Jinfeng,Jiang, Xiaofei,Li, Xuegang
supporting information, p. 7194 - 7197 (2013/01/15)
A series of hesperidin derivatives were prepared and identified by IR, 1H NMR, and MS spectra. These compounds were evaluated in vitro and in vivo based on α-glucosidase inhibition, glucose consumption of HepG2 cells, and blood glucose level in streptozotocin-induced diabetic mice. The results revealed that all the compounds exhibited anti-hyperglycemic activities. The inhibition at 10-3 M of compounds 3 and 7a on α-glucosidase were 55.02% and 53.34%, respectively, as compared to 54.80% by acarbose. Treated by compound 3 and the reference drug metformin, glucose consumption of HepG2 cell were 1.78 and 2.11 mM, respectively. After the streptozotocin-induced diabetic mice were oral administrated with compound 3 at 100 mg kg-1 d-1 for 10 days, the blood glucose level of 3 treated mice (13.23 mM, P 0.05) showed significant difference when compared to model control (23.03 mM). Thus, compound 3 exhibited promising anti-hyperglycemic activity.
Hypocholesterolemic activity of hesperetin derivatives
Jeong, Tae-Sook,Kim, Eun Eai,Lee, Chul-Ho,Oh, Jung-Hoon,Moon, Surk-Sik,Lee, Woo Song,Oh, Goo-Taeg,Lee, Sangku,Bok, Song-Hae
, p. 2663 - 2665 (2007/10/03)
Hesperetin ester and ether derivatives possessing a long alkyl chain were synthesized for examining their hypocholesterolemic activities in high cholesterol-fed mice. Hesperetin 7-O-lauryl ether (4b) and hesperetin 7-O-oleyl ether (4e) exhibited strong cholesterol-lowering effects.
Reduction of flavanones by cyanoborohydride sodium in trifluoroacetic acid. I
Lewin,Bert,Dauguet,Schaeffer,Guinamant,Volland
, p. 7049 - 7052 (2007/10/02)
Reduction of natural flavAnones with NaBH3CN in CF3cOOH gives, depending on substituents 7 and 4', either flavanes or 1,3-diaryl propanes.
