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Relevant academic research and scientific papers

Study of non-covalent interaction between a designed monoporphyrin and fullerenes (C60 and C70) in absence and presence of silver nanoparticles

The present article reports on supramolecular interaction between fullerenes (C60 and C70) and a designed monoporphyrin, e.g., 5,15-di(para-methoxyphenyl)zincporphyrin (1), in absence and presence of silver nanoparticles (AgNp) havin

Photophysical insights on effect of gold nanoparticles over fullerene-porphyrin interaction in solution

The present article reports the role of gold nanoparticles, i.e., AuNp (having diameter ～2-4 nm), in non-covalent interaction between fullerenes (C60 and C70) and a monoporphyrin (1) in toluene. Both UV-vis and fluorescence measureme

Design and synthesis of perpendicularly connected metal porphyrin-imide dyads for two-terminal wired single molecular diodes

Four different porphyrin-imide dyads bearing different central metals (zinc or rhodium) and different substituents on the porphyrin macrocycles (tert-butyl or methoxy) were synthesized for single molecular diode measurements. The molecules were designed to separate the donor component (porphyrin) from the acceptor component (imide) by bonding in a perpendicular arrangement, thus enhancing the rectification properties. UV/Vis absorption spectra and density functional theory calculations showed that the design was successful and that the molecular orbitals of the dyads were the summation of the two components, with minimal interaction between them. The effect of the central metal was found to be significant, with the lowest energy absorption for the zinc dyads being attributed to the mixed state of charge transfer from porphyrin to imide and the Q band, whereas that of the rhodium dyads indicated insignificant charge-transfer character. Molecular diodes: Four types of donor-acceptor molecules based on perpendicularly connected porphyrin and naphthalenediimide having different central metals, zinc(II) and rhodium(III), have been designed and synthesized to create donor-acceptor systems with the desired functionalities for single molecular diodes (see figure). The effects of central metals on molecular orbitals provide strong indications that the Rh porphyrin-imide dyads will show different electronic properties to the Zn molecules.

Comparison between 5,10,15,20-tetraaryl- and 5,15-diarylporphyrins as photosensitizers: Synthesis, photodynamic activity, and quantitative structure-activity relationship modeling

The synthesis of a panel of seven nonsymmetric 5,10,15,20- tetraarylporphyrins, 13 symmetric and nonsymmetric 5,15-diarylporphyrins, and one 5,15-diarylchlorin is described. In vitro photodynamic activities on HCT116 human colon adenocarcinoma cells were evaluated by standard cytotoxicity assays. A predictive quantitative structure-activity relationship (QSAR) regression model, based on theoretical holistic molecular descriptors, of a series of 34 tetrapyrrolic photosensitizers (PSs), including the 24 compounds synthesized in this work, was developed to describe the relationship between structural features and photodynamic activity. The present study demonstrates that structural features significantly influence the photodynamic activity of tetrapyrrolic derivatives: diaryl compounds were more active with respect to the tetraarylporphyrins, and among the diaryl derivatives, hydroxy-substituted compounds were more effective than the corresponding methoxy-substituted ones. Furthermore, three monoarylporphyrins, isolated as byproducts during diarylporphyrin synthesis, were considered for both photodynamic and QSAR studies; surprisingly they were found to be particularly active photosensitizers.

METHOD FOR PREPARING PORPHYRIN DERIVATE

The present invention relates to a method for manufacturing porphyrin derivatives, comprising a step of oxidizing porphyrinogen by oxygen bubbling under a metal catalyst to synthesize porphyrin derivatives. Therefore, since the method for manufacturing porphyrin derivatives of the present introduced a method of oxidization using oxygen bubbling under the metal catalyst without using a quinone-based oxidizing agent, it is possible to increase the yield of porphyrin derivatives and have an effect that a refining process is very easy.COPYRIGHT KIPO 2019

Electrochemical, Spectroelectrochemical, and Structural Studies of Mono- and Diphosphorylated Zinc Porphyrins and Their Self-Assemblies

Three series of porphyrins containing a Zn(II) central metal ion and zero, one, or two phosphoryl groups at the meso-positions of the macrocycle were characterized as to their electrochemical, spectroscopic, and structural properties in nonaqueous media.

An efficient synthesis of porphyrins with different meso substituents that avoids scrambling in aqueous media

We have developed new conditions that afford regioisomerically pure trans-A2B2-, A3B-, and trans-AB2C-porphyrins bearing aryl and arylethynyl substituents. The porphyrins were prepared by the acid-catalyzed condensation of dipyrromethanes with aldehydes followed by oxidation with p-chloranil or 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). Optimal conditions for the condensation were identified after examining various reaction parameters such as solvent composition, acid concentration, and reaction time. The conditions identified (for aromatic aldehydes: EtOH/H2O 4:1, [DPM] = 4 mM, [aldehyde] = 4 mM, [HCl] = 38 mM, 16 h; for arylethynyl aldehydes: THF/H2O 2:1, [DPM] = 13 mM, [aldehyde] = 13 mM, [HCl] = 150 mM, 3 h) resulted in the formation of porphyrins in yields of 9-38% without detectable scrambling. This synthesis is compatible with diverse functionalities such as ester or nitrile. In total, 20 new trans-A2B2-, A3B-, and trans-AB2C-porphyrins were prepared. The scope and limitations of the two sets of reaction conditions have been explored. The methodological advantage of this approach is its straightforward access to building blocks and the formation of the porphyrin core in higher yields than by any other methodology and by using environmentally benign and nonhazardous chemicals.

ANTI-APOPTOTIC BENZODIAZEPINE RECEPTOR LIGAND INHIBITORS

The present invention provides low molecular weight porphyrin compositions for inhibiting, preventing or delaying the binding of a ligand of a mitochondrial benzodiazepine receptor. The invention also provides pharmaceutical compositions comprising these porphyrin compositions and their use in the treatment of conditions involving the mitochondrial benzodiazepine receptor or interactions between the receptor and the mitochondrial permeability transition pore e.g., drug overdose or apoptosis including neural degeneration and radiation-induced apoptosis.

Lead structures for applications in photodynamic therapy. Part 1: Synthesis and variation of m-THPC (Temoporfin) related amphiphilic A2BC-type porphyrins

Photodynamic therapy (PDT) is a developing modality for the treatment of certain tumorous and other diseases. Considerable progress has been made in recent years in the search for new photosensitizers, in particular elucidating the role of localization of

Colorimetric calcium-response of β-lactosylated μ-oxo-bis-[5,15- meso-diphenylporphyrinatoiron(III)]

β-Lactosylated 5,15-meso-diphenylporphyrinatoiron(III) chloride was prepared by ironization of the corresponding free base porphyrin having acetylated lactoside-units followed by deacetylation with ammonia in a water-methanol mixture. The resultant 5,15-m