1283751-65-4Relevant academic research and scientific papers
TMSOTf-catalyzed synthesis of substituted quinazolines using hexamethyldisilazane as a nitrogen source under neat and microwave irradiation conditions
Chan, Chieh-Kai,Lai, Chien-Yu,Wang, Cheng-Chung
, p. 7201 - 7212 (2020)
In this article, we report an efficient and mild synthetic route for the construction of substituted quinazolines from functionalized 2-aminobenzophenones with various benzaldehydes usingcat. TMSOTf and hexamethyldisilazane (HMDS) under neat, metal-free and microwave irradiation conditions in which gaseous ammonia was formedin situ. This synthetic protocol provided the desired quinazolines with a broad substrate scope in good to excellent yields. Some structures were confirmed by X-ray single-crystal diffraction analysis.
Microwave-promoted efficient synthesis of dihydroquinazolines
Sarma, Rupam,Prajapati, Dipak
supporting information; experimental part, p. 718 - 722 (2011/05/03)
A solvent- and catalyst-free synthesis of dihydroquinazolines is described. 2,4-Disubstituted-1,2-dihydroquinazolines can be readily obtained from 2-aminobenzophenone and aldehydes under microwave irradiation using urea as an environmentally benign source
