128404-12-6Relevant academic research and scientific papers
Design of high-affinity peptide conjugates with optimized fluorescence quantum yield as markers for small peptide transporter PEPT1 (SLC15A1)
Bahadduri, Praveen M.,Ray, Abhijit,Khandelwal, Akash,Swaan, Peter W.
, p. 2555 - 2557 (2008/12/21)
We employed a computational approach to design and synthesize a series of fluorescently labeled hPEPT1 substrates. Five Alexa Fluor-350-labeled peptides were assessed for their in vitro inhibitory activity in hPEPT1-transfected CHO cells. At least four labeled peptides show potent inhibitory activity toward hPEPT1-mediated uptake of [3H]-GlySar and three compounds displayed a significant cellular uptake specifically mediated by hPEPT1.
