2389-46-0Relevant academic research and scientific papers
A simple synthesis of imide-dipeptides
Ke, Damei,Zhan, Chuanlang,Li, Xiao,Li, Alexander D. Q.,Yao, Jiannian
experimental part, p. 1506 - 1510 (2009/12/24)
We report a simple approach to synthesize a new class of imide-dipeptides. This approach is mild, and the starting materials are the easily accessible amino acid derivatives. The imide-dipeptides were synthesized from the coupling of an amide and a 4-nitrophenyl activating ester of an amino acid. The acidic proton of the first amide was removed by 1 equivalent of n-butyl lithium to afford the corresponding amide anion which then reacted with the activating ester to give the desired imide derivatives. Georg Thieme Verlag Stuttgart.
INVESTIGATION ON PEPTIDE SYNTHESIS BY FRAGMENT CONDENSATION. PART I. SYNTHESIS OF C1 - C4 FRAGMENT OF SUBSTANCE P IN SOLUTION AND BY THE SOLID PHASE METHOD
Orlowska, Alicja,Drabarek, Stefania
, p. 1893 - 1899 (2007/10/02)
The synthesis of protected tetrapeptide Z3-Arg-Pro-Lys(Z)-Pro-OH corresponding to C1 - C4 fragment of substance P in solution and by the solid phase method has been elaborated.
