128405-56-1

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 79-24-3 Nitroethane 
• 100-46-9 benzylamine 
• 20540-69-6 pentacarbonyl(methoxymethylcarbene)chromium⁽⁰⁾ 
• 104-55-2 3-phenyl-propenal 
• 119353-37-6 (E,E)-4-aza-1,5-diphenylpenta-1,3-diene 
• 917-54-4 methyllithium 

Relevant academic research and scientific papers

Modular Domino Process toward Highly Functionalized Pyrroles via Pd-Catalyzed [4 + 1] Annulation under Mild Conditions

A Pd-catalyzed decarboxylative approach for the modular synthesis of highly functionalized pyrroles is presented. This protocol utilizes readily available cyclic carbonates and amines as reaction partners and only generates CO2 and H2O as byproducts. This methodology could be operated at room temperature and open to air, thus serving as an ideal means for the derivatization of bioactive compounds. Mechanism investigations suggested that the stereoselective formation of the (Z)-configured γ-amino ketone intermediate is crucial for the success of the reaction.

Synthesis of pyrroles: Reaction of chromium N-alkylaminocarbene complexes with α,β-unsaturated aldehydes

N-Alkylaminocarbene complexes of chromium were found to react with α,β-unsaturated aldehydes to give pyrroles in good yields. The Royal Society of Chemistry 2006.

Synthesis of alkyl-substituted pyrroles by three-component coupling of carbonyl compound, amine and nitro-alkane/alkene on a solid surface of silica gel/alumina under microwave irradiation

Efficient synthesis of highly substituted alkylpyrroles and fused pyrroles has been achieved by a three-component coupling of (a) α,β-unsaturated aldehyde/ketone, amine and nitroalkane and (b) α,β-unsaturated nitroalkene, aldehyde/ketone and amine on the surface of silica gel and alumina without any solvent under microwave irradiation.

Microwave-assisted synthesis of substituted pyrroles by a three- component coupling of α,β-unsaturated carbonyl compounds, amines and nitroalkanes on the surface of silica gel

An improved procedure has been developed for the synthesis of highly substituted pyrroles through a simple one-pot reaction of α,β-unsaturated aldehydes/ketones, amines and nitroalkanes on the surface of silica gel without any solvent under microwave irradiation.

Nucleophilic addition to tricarbonyliron(0) complexes of 1-aza-1,3-dienes and the production of pyrroles

The synthesis of a number of novel tricarbonyl(1-aza-1,3-diene)iron(0) complexes and their reactions with methyl-lithium are described. Addition proceeds under mild conditions and, in general, occurs at a metal carbonyl ligand; this leads via an unprecedented reaction to the production of several novel pyrroles.