1284215-29-7Relevant academic research and scientific papers
SMALL MOLECULES THAT COVALENTLY MODIFY TRANSTHYRETIN
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Page/Page column 119; 123-124, (2011/07/07)
A family of covalent kinetic stabilizer compounds that selectively and covalently react with the prominent plasma protein transthyretin in preference to more than 4000 other human plasma proteins is disclosed. A contemplated compound corresponds in struct
A stilbene that binds selectively to transthyretin in cells and remains dark until it undergoes a chemoselective reaction to create a bright blue fluorescent conjugate
Choi, Sungwook,Ong, Derrick Sek Tong,Kelly, Jeffery W.
supporting information; experimental part, p. 16043 - 16051 (2011/02/16)
We describe a non-fluorescent, second generation stilbene that very selectively binds to transthyretin in complex biological environments and remains dark until it chemoselectively reacts with the pKa-perturbed Lys-15 ε-amino group of transthyr
