1284216-89-2Relevant academic research and scientific papers
ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS
-
Page/Page column 117-118, (2011/04/26)
Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): (Formula (I)), including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Hybrid aminoglycoside antibiotics via tsuji palladium-catalyzed allylic deoxygenation
Hanessian, Stephen,Maianti, Juan Pablo,Matias, Rowena D.,Feeney, Lee Ann,Armstrong, Eliana S.
supporting information; experimental part, p. 6476 - 6479 (2012/02/14)
Biosynthetically inspired manipulation of the antibiotic paromomycin led, in six high-yielding steps, to a ring A harboring an R,β-unsaturated 6′- aldehyde and an allylic 3′-methylcarbonate group. Tsuji deoxygenation in the presence of 5 mol % Pd2(dba)3 and Bu3P granted access to a novel series of 3′,4′-dideoxy- 4′,5′-dehydro ring A hybrids. The neomycin-sisomicin hybrid exhibited superior in vitro antibacterial activity to the parent compound neomycin.
