128422-13-9

Basic information

• Product Name: L-Proline, 1-[2-methyl-N-[N-[(phenylmethoxy)carbonyl]-L-leucyl]alanyl]-, 1,1-dimethylethyl ester
• CAS NO: 128422-13-9
• Molecular Formula: C27H41N3O6
• Molecular Weight: 503.639
• Mol File: 128422-13-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: L-Proline, 1-[2-methyl-N-[N-[(phenylmethoxy)carbonyl]-L-leucyl]alanyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, 1-[2-methyl-N-[N-[(phenylmethoxy)carbonyl]-L-leucyl]alanyl]-, 1,1-dimethylethyl ester(128422-13-9)
• EPA Substance Registry System: L-Proline, 1-[2-methyl-N-[N-[(phenylmethoxy)carbonyl]-L-leucyl]alanyl]-, 1,1-dimethylethyl ester(128422-13-9)

Safety Data

• Hazardous Substances Data: 128422-13-9(Hazardous Substances Data)

Upstream product

• 128422-06-0 Z-Leu-Aib-NMe₂ 
• 128422-11-7 N-[(benzyloxy)carbonyl]leucyl-α-aminoisobutyric acid 
• 5497-76-7 L-proline tert-butyl ester hydrochloride 
• 83283-35-6 Proline tert-butyl ester dibenzenesulfimide salt 
• 2018-66-8 Z-Leu-OH 
• 132682-09-8 H-Aib-Pro-OtBu*HCl 
• 2812-46-6 proline tert-butyl ester 
• 132682-05-4 tert-butyl (2-(((benzyloxy)carbonyl)amino)-2-methylpropanoyl)-L-prolinate 
• 132682-08-7 Z-L-Leu-Aib-OAllyl 
• 132682-10-1 Z-D-Leu-Aib-OMe 
• 28862-79-5 Z-D-Leu-OH 

Downstream Products

• 128422-09-3 Z-Leu-Aib-Pro-Val-Aib-Aib-Glu(OBzl)-Gln-Pheol 
• 128422-08-2 Z-Leu-Aib-Pro-Val-Aib-Aib-NMe(Ph) 
• 128422-23-1 Z-Leu-Aib-Pro-Val-Aib-Aib-OH 
• 128422-17-3 Z-Leu-Aib-Pro-OH 
• 84758-76-9 Z-L-Leu-Aib-L-Pro-OMe 
• 128422-11-7 N-[(benzyloxy)carbonyl]leucyl-α-aminoisobutyric acid 

Relevant articles and documents

PyBOP and PyBroP: Two reagents for the difficult coupling of the α,α-dialkyl amino acid, Aib

The difficult coupling of α-aminoisobutyric acid (Aib) was carried out using PyBOP and PyBroP in a comparative study with BOP and BroP. These reagents gave good results under simple conditions (one pot, r.t., 1h). Coded amino acids could be coupled with Aib using PyBOP under standard conditions of peptide synthesis without racemization whereas the coupling of two Aib residues required PyBroP/DMAP. A fragment containing an Aib C-terminal could be coupled without epimerization of the penultimate residue.