5497-76-7 Usage
Uses
Used in Pharmaceutical Research:
tert-Butyl L-prolinate hydrochloride is used as a key component in peptide synthesis for pharmaceutical research. Its role in the synthesis process is crucial for the development of new drugs and therapeutic compounds.
Used in Biochemistry:
In the field of biochemistry, tert-Butyl L-prolinate hydrochloride is used as a reagent for studying the properties and interactions of amino acids, particularly L-proline, and their derivatives. This helps in understanding the fundamental aspects of protein structure and function.
Used in Drug Formulation:
tert-Butyl L-prolinate hydrochloride is used as an ingredient in the formulation of drugs, where its involvement in peptide synthesis can contribute to the development of novel therapeutic agents with improved efficacy and safety profiles.
It is important to handle tert-Butyl L-prolinate hydrochloride with care, store it under proper conditions, and avoid disposing of it in the environment to minimize potential risks.
Check Digit Verification of cas no
The CAS Registry Mumber 5497-76-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,4,9 and 7 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 5497-76:
(6*5)+(5*4)+(4*9)+(3*7)+(2*7)+(1*6)=127
127 % 10 = 7
So 5497-76-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H17NO2.ClH/c1-9(2,3)12-8(11)7-5-4-6-10-7;/h7,10H,4-6H2,1-3H3;1H/t7-;/m0./s1
5497-76-7Relevant academic research and scientific papers
STUDIES ON AMINO ACIDS AND PEPTIDES X. HPLC-MEDIATED TEST OF 2,4-BIS(4-METHOXYPHENYL)-1,3,2,4-DITHIADIPHOSPHETANE 2,4-DISULFIDE (LAWESSONS'S REAGENT) AS A RACEMIZATIONFREE COUPLING REAGENT IN PEPTIDE SYNTHESIS
Thorsen, M.,Andersen, T. P.,Pedersen, U.,Yde, B.,Lawesson, S.-O.,Hansen. H. F.
, p. 5633 - 5636 (2007/10/02)
The easily available 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide (Lawesson's Reagent), 1, has been tested as a coupling reagent for racemization in peptide synthesis.The assay procedure is separation of stereomeric products by HPLC.Z-S-Pro-S-Val-S-Pro-OtBu and Z-S-Leu-S-Phe-S-Val-OtBu have been used as test peptides in 2+1 segment couplings, and only a small amount of epimerization (0.5 and 0.1percent, respectively) has been observed.
