1284281-37-3

Upstream product

• 1264088-38-1 ethyl chloro[(3-bromophenyl)hydrazono]acetate 
• 91890-10-7 1-(4-morpholinyl)-1-(4-methoxyphenyl)-ethene 
• 591-19-5 m-Bromoaniline 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 35322-20-4 ethyl 3-(4-methoxybenzoyl)pyruvate 
• 40887-80-7 3-bromophenylhydrazine 

Downstream Products

• 1314017-94-1 C₁₇H₁₂Br₂N₂O₃ 
• 1284281-38-4 ethyl 4-bromo-1-(3-bromophenyl)-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate 
• 1284281-59-9 4-bromo-1-(3-bromophenyl)-N-(4-cyanotetrahydro-2H-pyran-4-yl)-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide 

Relevant academic research and scientific papers

Diphenylpyrazoles as replication protein A inhibitors

Replication Protein A is the primary eukaryotic ssDNA binding protein that has a central role in initiating the cellular response to DNA damage. RPA recruits multiple proteins to sites of DNA damage via the N-terminal domain of the 70 kDa subunit (RPA70N). Here we describe the optimization of a diphenylpyrazole carboxylic acid series of inhibitors of these RPA-protein interactions. We evaluated substituents on the aromatic rings as well as the type and geometry of the linkers used to combine fragments, ultimately leading to submicromolar inhibitors of RPA70N protein-protein interactions.

N -(4-cyanotetrahydro-2 H -pyran-4-yl) and N -(1-cyanocyclohexyl) derivatives of 1,5-diarylpyrazole-3-carboxamides showing high affinity for 18 kDa translocator protein and/or cannabinoid receptors

In order to develop improved radioligands for imaging brain CB1 receptors with positron emission tomography (PET) based on rimonabant (5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl) -1H-pyrazole-3-carboxamide, 1), we synt