128441-13-4

Basic information

• Product Name: 1,4-Dithiaspiro[4.5]decan-7-ol
• Synonyms: 1,4-Dithiaspiro[4.5]decan-7-ol
• CAS NO: 128441-13-4
• Molecular Formula: C8H14OS2
• Molecular Weight: 190.32616
• Mol File: 128441-13-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,4-Dithiaspiro[4.5]decan-7-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dithiaspiro[4.5]decan-7-ol(128441-13-4)
• EPA Substance Registry System: 1,4-Dithiaspiro[4.5]decan-7-ol(128441-13-4)

Safety Data

• Hazardous Substances Data: 128441-13-4(Hazardous Substances Data)

Usage

Type of compound

Chemical compound

Structure

Spiro ring structure

Contains

Two sulfur atoms

Category

Spiro cyclic compound

Potential use

Pharmaceuticals and other chemical applications

Ongoing research

Synthesis and potential applications

Studied for

Biological and pharmacological properties

Upstream product

• 504-02-9 1,3-cylohexanedione 
• 80563-98-0 1,4-dithiaspiro<4.5>decan-7-one 

Relevant articles and documents

The substrate- and stereoselectivity of microbial reductions of 1,4-dithiaspirodecanones and 1,5-dithiaspiroundecanones

The title spirocyclic ketones, possessing possible substitution patterns 1,4-dithiaspirodecan-6-one (1a), -7-one (3a), and -8-one (5a) and 1,5-dithiaspiroundecan-7-one (2a), -8-one (4a), and -9-one (6a), have been reduced with new strains of yeast (Saccharomyces cerevisiae, JCM 1819 and JCM 2214).Reductions of the prochiral ketones 1a-4a occur with high enantiofacial selectivity on the preparative scale (up to 99percent ee).The product alcohols (1,4-dithiaspirodecan-6-ol (1b) and -7-ol (3b) and 1,5-dithiaspiroundecan-7-ol (2b) and -8-ol (4b)) have theS configuration, as confirmed by 2D COSY experiments of the (S)-MTPA ester of 1b-4b using the configuration correlation model of Mosher.