128451-11-6Relevant academic research and scientific papers
Synthesis and cytotoxic activity of heterocyclization products of 1,1-dicyano-2-hetaryl-2-trifluoromethylethylenes
Pavlova,Shidlovskii,Gusev,Peregudov,Bulychev,Chkanikova
experimental part, p. 162 - 176 (2011/01/09)
Methods for the synthesis of novel fluorinated compounds by reaction of 1,1-dicyano-2-hetaryl-2-trifluoromethylethylenes with a variety of nitrogen heterocycles have been developed. Cyctotoxicity of the obtained organofluorine heterocycles were studied in vitro at the U.S. National Cancer Institute (NCI) in the framework of the International Program for Development of Effective Antitumor Drugs. Cytotoxic activity in the series of fluorinated pyrazolo[1,5-a]pyrimidines has been observed for the first time, this strongly depending on the nature and position of the substituents.
(α-PERFLUOROHEPTYL-β,β-DICYANOVINYL)AMINOSTYRENES: A NOVEL CLASS OF PERFLUOROCARBON-SOLUBLE DYES
Freed, Bethany K.,Middleton, W. J.
, p. 219 - 225 (2007/10/02)
Several examples of (α-perfluoroheptyl-β,β-dicyanovinyl)aminostyrenes (3), a novel class of perfluorocarbon-soluble dyes, were prepared by the reaction of 2-chloro-1,1-dicyano-2-(perfluoroheptyl)ethylene (2) with aromatic amines.The ethylene 2 was prepared from methyl perfluorooctanoate, malononitrile, and phosphorous pentachloride.The λmax for perfluorohexane solutions of the dyes ranges from 419 nm for the dye prepared from N-phenylmorpholine to 490 nm for the dye prepared from julolidine.
