128455-33-4Relevant articles and documents
SYNTHESIS OF DIASTEREOISOMERS OF DIMETHYL 4-ARYLAMINO-N-PHTHALOYL-L-GLUTAMATES
Nizova, I. A.,Krasnov, V. P.,Korotovskikh, O. V.,Alekseeva, L. V.
, p. 2545 - 2549 (2007/10/02)
Reaction of p-substituted arylamines with dimethyl (2S,4RS)-4-bromo-N-phthaloylglutamate followed by separation of the stereoisomers has given the pure dimethyl (2S)-4-arylamino-N-phthaloylglutamates.Nucleophilic replacement of the halogen in dimethyl (2S,4RS)-4-bromo-N-phtaloylglutamate is diastereoselective, giving the threo-isomer preferentially.