128458-22-0Relevant academic research and scientific papers
Thioglycolic acid and pyrazole derivatives of 4(3H)-quinazolinone: Synthesis and antimicrobial evaluation
Farghaly,Soliman,Khalil,Bekhit,Bekhit, A.El-Din A.
, p. 372 - 378 (2007/10/03)
New derivatives of 4(3H)-quinazolinone were synthesized and evaluated for their antibacterial and antifungal activity. The derivatives are: 3-Aryl-2-[3-aryl-1-(carboxymethylthio)-3-oxopropyl)]-4(3H)-quina-zolinones 2a-f; 3-Aryl-2-(3-aryl-1H-pyrazol-5-yl)-4(3H)-quinazolinones 3a-f; 3-Aryl-2-(1,3-diaryl-1H-pyrazol-5-yl)-4(3H).quinazolinones 4af; 3-Aryl-2-(3-aryl-1-thiocarbamoyl-1H-pyrazol-5-yl)-4(3H)-quinazolinones 5a-f; 3-Aryl-2.[3-aryl-1-(carboxymethylthio)-3-hydroxyiminopropyl)]-4 (3H)-quinazolinones 6a-f; and 3-Aryl-2[3-aryl-1-(carboxymethy-lthio)-3-thiocarbamoyliminopropyl)] -4(3H)-quinazolinones 7a-f. Some of the tested compounds showed activity comparable to that of the standard references used.
