2385-23-1

Basic information

• Product Name: 2-methyl-3-phenyl-quinazolin-4-one
• Synonyms: 2-methyl-3-phenyl-quinazolin-4-one;2-methyl-3-phenylquinazolin-4-one;2-METHYL-3-PHENYL-4(3H)-QUINAZOLINONE
• CAS NO: 2385-23-1
• Molecular Formula: C₁₅H₁₂N₂O
• Molecular Weight: 236.26858
• Mol File: 2385-23-1.mol
• Article Data: 49

Chemical Properties

• Boiling Point: 396.2°Cat760mmHg
• Flash Point: 193.4°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 1.74E-06mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: 2-methyl-3-phenyl-quinazolin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-3-phenyl-quinazolin-4-one(2385-23-1)
• EPA Substance Registry System: 2-methyl-3-phenyl-quinazolin-4-one(2385-23-1)

Safety Data

• Hazardous Substances Data: 2385-23-1(Hazardous Substances Data)

Usage

General Description

2-methyl-3-phenyl-quinazolin-4-one, also known as mepyramine, is an organic compound with the molecular formula C17H16N2O. It is a histamine H1 receptor antagonist, which means it binds to and blocks the activity of histamine at H1 receptors, leading to its use as an antihistamine. Mepyramine is commonly used as a first-generation antihistamine to treat allergic reactions, itching, and insect bites. It has been found to have sedative and antiemetic effects as well, making it useful in treating motion sickness and preventing nausea and vomiting. However, it may cause drowsiness and other side effects, and has largely been replaced by newer, non-sedating antihistamines in many clinical settings.

InChI:InChI=1/C15H12N2O/c1-11-16-14-10-6-5-9-13(14)15(18)17(11)12-7-3-2-4-8-12/h2-10H,1H3

Upstream product

• 118-48-9 isatoic anhydride 
• 621-09-0 N,N'-diphenylacetamidine 
• 62-53-3 aniline 
• 108-88-3 toluene 
• 89-52-1 o-acetylamino-benzoic acid 
• 7719-12-2 phosphorus trichloride 
• 118-92-3 anthranilic acid 
• 103-84-4 Acetanilid 
• 10025-87-3 trichlorophosphate 
• 71-43-2 benzene 
• 17761-74-9 2-methyl-3-phenyl-2,3-dihydro-1H-quinazolin-4-one 
• 615-43-0 2-iodophenylamine 
• 108-24-7 acetic anhydride 
• 98-95-3 nitrobenzene 

Downstream Products

• 52458-00-1 2-methyl-4,4-diphenyl-4H-benzo[d][1,3]oxazine 
• 30507-24-5 2-(p-Methoxyphenethylene)-3-phenyl-4(3H)-quinazolinone 
• 22219-15-4 1,4-diphenylimidazo[1,5-a]quinazolin-5(4H)-one 

Relevant articles and documents

(E)-2-(hydroxystyryl)-3-phenylquinazolin-4(3H)-ones: Synthesis, photochemical and luminescent properties

The new (E)-2-(hydroxyarilethenyl)-3-phenylquinazolin-4(3H)-ones with various substituents in phenyl fragment were synthesized. The effect of electron donor and acceptor substituents (±M) in quinazolinones on luminescence intensity and dual emission in 55

Development of novel Schiff base fluorophores for selective detection of Cu2+ ions in seawater using test strips

A novel Schiff bases of 2-((2-aminophenylimino)methyl)-3-phenyl-4(3H)-quinazolinone (3a), 2-((2-aminophenylimino)methyl)-3-(4-tolyl)-4(3H)-quinazolinone (3b), and 2-((2-aminophenylimino)methyl)-3-(4-anisyl)-4(3H)-quinazolinone (3c) were synthesized and ch

Metal-free C-H methylation and acetylation of heteroarenes with PEG-400

The generation of a methyl carbon source from renewable and cheap sources is challenging. Herein, we describe a novel and an efficient route for methylation and acetylation of aza-heteroarenes using PEG-400 under O2and TsOH·H2O for the first time by tuning the reaction conditions using a different set of starting materials. The key features of the current protocol are oxidative C-O and C-C bond scission under metal-free conditions with good functional group tolerance, and a broad substrate scope. The potential applicability of the designed methodology was demonstrated for the synthesis of central nervous system (CNS) depressant and anticonvulsant drug molecules by a one-pot strategy.

Screening of natural deep eutectic solvents for green synthesis of 2-methyl-3-substituted quinazolinones and microwave-assisted synthesis of 3-aryl quinazolinones in ethanol

In this study, two fast and efficient protocols for green synthesis of 3-substituted quinazolinones were perfomed. A synthesis of 2-methyl-3-substituted quinazolinones was performed in natural deep eutectic solvents, while 3-aryl quinazolinones were obtained by using microwave assisted synthesis. Benzoxazinone, which was used as an intermediate in the synthesis of 2-methyl-3-substituted quinazolinones, was prepared conventionally from anthranilic acid and acetic anhydride. In order to find the most appropriate synthetic path, twenty natural deep eutectic solvents were applied as a solvent in these syntheses. Choline chloride:urea (1: 2) was found to be the most efficient solvent and was further used in the synthesis of 2-methyl quinazolinone derivatives (2–12). 3-Aryl quinazolinones (13–17), on the other hand, were synthesized in one-pot microwave-assisted reaction of anthranilic acid, different amines and trimethyl orthoformate. All compounds were synthesized in good to excellent yields, characterized by LC-MS/MS spectrometry and 1H- and 13C-NMR spectroscopy.