128479-39-0Relevant academic research and scientific papers
Efficient one-pot synthesis of biologically active polysubstituted aromatic amines
Menche, Dirk,Arikan, Fatih,Li, Jun,Rudolph, Sven,Sasse, Florenz
, p. 7311 - 7317 (2007)
An efficient and modular one-pot synthesis of polysubstituted aromatic amines by a mild reductive amination procedure is described and the biological potential of these nitrogen-centered compounds is demonstrated by growth inhibition of murine connective tissue cells and microscopy-based morphological studies.
Solvent- and catalyst-free direct reductive amination of aldehydes and ketones with Hantzsch ester: Synthesis of secondary and tertiary amines
Nguyen, Quynh Pham Bao,Kim, Taek Hyeon
, p. 4938 - 4943 (2013/07/25)
A facile and rapid method for the parallel synthesis of a series of secondary and tertiary amines by the direct reductive amination of aldehydes and ketones with Hantzsch ester under solvent- and catalyst-free has been developed. The scope and limitation of this method are described.
Synthesis of hindered tertiary amines by a mild reductive amination procedure
Menche, Dirk,B?hm, Stefanie,Li, Jun,Rudolph, Sven,Zander, Wiebke
, p. 365 - 369 (2007/10/03)
An efficient metal-free procedure for the synthesis of tertiary amines by the reductive amination of carbonyl compounds is reported, which allows a convergent access to sterically hindered amines of the general formulas NR(R′)2 and NRR′R″. The mild and operationally simple protocol uses the Hantzsch ester for transfer hydrogenation and catalytic amounts of thiourea for imine activation.
A versatile method for the N,N-dialkylation of aromatic amines via Grignard reactions on N,N-bis(benzotriazolylmethyl)arylamines
Katritzky, Alan R.,Rachwal, Stanislaw,Wu, Jing
, p. 456 - 463 (2007/10/02)
Grignard reactions of N,N-bis(benzotriazolylmethyl)arylamines afford the corresponding N,N-dialkylarylamines in high yields.Electron-releasing substituents on the aryl ring facilitate the reaction.Arylamines are N,N-dialkylated with two different alkyl groups by a stepwise procedure: N-benzotriazolylmethylation of an amine followed by a Grignard reaction to introduce the first alkyl group, and repetition of the same procedure to introduce the second alkyl group.Grignard reagents derived from 1,4-dihalobutane, upon reaction with N,N-bis(benzotriazolylmethyl)arylamines, give the corresponding N-aryl-hexahydroazepines together with acyclic products.
