128483-29-4

Upstream product

• 59082-25-6 2-(4-fluorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 459-57-4 4-fluorobenzaldehyde 
• 128483-25-0 2-Mercapto-4-p-fluorophenyl-4H-1,2,3,4,5,6-hexahydrobenzo-quinazoline 
• 79-11-8 chloroacetic acid 

Downstream Products

• 128483-33-0 2-(p-fluorophenylmethylene)-5-p-fluorophenyl-5H-2,3,6,7-tetrahydrobenzothiazolo<2,3-b>quinazoline-3-one 
• 1222377-01-6 (Z)-3-(5-((7-(4-fluorophenyl)-9-oxo-5H-benzo[h]thiazolo[2,3-b]quinazolin-10(6H,7H,9H)-ylidene)methyl)furan-2-yl)benzoic acid 

Relevant academic research and scientific papers

Design, synthesis, and interaction study of quinazoline-2(1 H)-thione derivatives as novel potential Bcl-xL inhibitors

Development of inhibitors to antagonize the activities of antiapoptotic Bcl-2 family proteins is of particular interest in cancer chemotherapy. We discovered a quinazoline-2(1H)-thione derivative (DCBL55) as a new Bcl-x L, Bcl-2, and Mcl-1 inhi

SYNTHESIS AND REACTIONS OF 2-MERCAPTO-4-ARYL 4H-1,2,3,4,5,6-HEXAHYDRO-BENZOQUINAZOLINES

2-Mercapto-4-aryl-4H-1,2,3,4,5,6-hexahydrobenzoquinazolines (2), have been synthesized.Compounds 2 reacted with chloroacetic acid, 2-bromopropanoic acid or 3-bromopropanoic acid in the presence of fused sodium acetate and acetic anhydride to give 5-ary