128486-73-7Relevant articles and documents
LACTAM DERIVATIVES
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, (2008/06/13)
The invention provides potent and selective antagonists of 5-HT at 5-HT 3 receptors which are tricyclic lactams of the formula (I) STR1 wherein Im represents an imidazolyl group of the formula: STR2 and R. sup.1 represents a hydrogen atom or a group selected from C 1-6 alkyl, C. sub.3-6 alkenyl, C 3-10 alkynyl, C 3-7 cycloalkyl, C 3-7 cycloalkylC 1-4 alkyl, phenyl, phenylC 1-3 alkyl,--CO 2 R. sup.5,--COR 5,--CONR 5 R 6 or--SO 2 R 5 ;one of the groups represented by R 2, R. sup.3 and R 4 is a hydrogen atom or a C 1-6 alkyl, C 3-7 cycloalkyl, C 3-6 alkenyl, phenyl or phenylC 1-3 alkyl group, and each of the other two groups, which may be same or different, represents a hydrogen atom or a C 1-6 alkyl group;Y represents the group CH=CH or (CH 2) n, wherein n represents 2 or 3;Q represents a halogen atom, or a group selected from hydroxy, C 1-4 alkoxy, phenylC 1-3 alkoxy, C 1-6 alkyl, cyano, phenyl which may be unsubstituted or substituted by one or more C 1-4 alkyl, C 1-4 alkoxy or hydroxy groups or halogen atoms,--NR 7 R 8,--CONR 7 R. sup.8 ,--(CH 2) p CONR 7 R 8,--(CH 2) q NR 9 R 10 or--(CH 2) 2 CO 2 R 11 ;Q' represents a hydrogen or a fluorine atom;and physiologically acceptable salts and solvates thereof.
