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122852-75-9

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122852-75-9 Usage

Uses

2,3,4,5-Tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one is useful for preparation of cyclic anti-azacarboxylation of alkynylanilines with carbon dioxide for preparation of indole-3-carboxylic acids.

Check Digit Verification of cas no

The CAS Registry Mumber 122852-75-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,8,5 and 2 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 122852-75:
(8*1)+(7*2)+(6*2)+(5*8)+(4*5)+(3*2)+(2*7)+(1*5)=119
119 % 10 = 9
So 122852-75-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H12N2O/c1-14-9-5-3-2-4-8(9)11-10(14)6-7-13-12(11)15/h2-5H,6-7H2,1H3,(H,13,15)

122852-75-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,3,4,5-Tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

1.2 Other means of identification

Product number -
Other names 2,3,3',4,4',5-HEXACDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:122852-75-9 SDS

122852-75-9Synthetic route

C18H18N2O2

C18H18N2O2

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In toluene at 110℃; Inert atmosphere;94%
2,3,4,5-tetrahydro-1H-pyrido-[4,3-b]indol-1-one
122852-78-2

2,3,4,5-tetrahydro-1H-pyrido-[4,3-b]indol-1-one

methyl iodide
74-88-4

methyl iodide

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

Conditions
ConditionsYield
Stage #1: 2,3,4,5-tetrahydro-1H-pyrido-[4,3-b]indol-1-one With sodium hexamethyldisilazane In N,N-dimethyl-formamide at 5℃; for 0.333333h; Inert atmosphere;
Stage #2: methyl iodide In N,N-dimethyl-formamide at 5℃; for 0.333333h;
72%
2,3,4,5-tetrahydro-1H-pyrido-[4,3-b]indol-1-one
122852-78-2

2,3,4,5-tetrahydro-1H-pyrido-[4,3-b]indol-1-one

dimethyl sulfate
77-78-1

dimethyl sulfate

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

Conditions
ConditionsYield
With sodium hydroxide In water; acetone
5,6-dihydro-4-(2-methyl-2-phenylhydrazino)-2(1H)-pyridinone
139122-76-2

5,6-dihydro-4-(2-methyl-2-phenylhydrazino)-2(1H)-pyridinone

sulfuric acid
7664-93-9

sulfuric acid

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

Conditions
ConditionsYield
With sodium hydroxide In water
With sodium hydroxide In water; acetic acid
N-(4-(2-aminophenyl)but-3-yn-1-yl)-4-methylbenzenesulfonamide
1416349-23-9

N-(4-(2-aminophenyl)but-3-yn-1-yl)-4-methylbenzenesulfonamide

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: pyridine / dichloromethane / 12 h / 0 - 20 °C / Schlenk technique; Inert atmosphere
2.1: diethylzinc / toluene; dimethyl sulfoxide / 10 h / 25 °C / 760.05 Torr / Schlenk technique
2.2: 3 h / 0 - 20 °C / Schlenk technique; Inert atmosphere
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / Schlenk technique; Reflux
4.1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C / Schlenk technique
5.1: sodium anthracenide / 1,2-dimethoxyethane / 1 h / -78 °C / Schlenk technique; Inert atmosphere
View Scheme
2-(4-(N-tosyl)amino-1-butynyl)-N-tosylaniline
1000205-65-1

2-(4-(N-tosyl)amino-1-butynyl)-N-tosylaniline

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: diethylzinc / toluene; dimethyl sulfoxide / 10 h / 25 °C / 760.05 Torr / Schlenk technique
1.2: 3 h / 0 - 20 °C / Schlenk technique; Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / Schlenk technique; Reflux
3.1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C / Schlenk technique
4.1: sodium anthracenide / 1,2-dimethoxyethane / 1 h / -78 °C / Schlenk technique; Inert atmosphere
View Scheme
2,3,4,5-tetrahydro-2,5-ditosyl-1H-pydrido[4,3-b]indole-1-one

2,3,4,5-tetrahydro-2,5-ditosyl-1H-pydrido[4,3-b]indole-1-one

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / Schlenk technique; Reflux
2: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C / Schlenk technique
3: sodium anthracenide / 1,2-dimethoxyethane / 1 h / -78 °C / Schlenk technique; Inert atmosphere
View Scheme
2,3,4,5-tetrahydro-2-tosyl-1H-pydrido[4,3-b]indole-1-one

2,3,4,5-tetrahydro-2-tosyl-1H-pydrido[4,3-b]indole-1-one

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C / Schlenk technique
2: sodium anthracenide / 1,2-dimethoxyethane / 1 h / -78 °C / Schlenk technique; Inert atmosphere
View Scheme
2-iodophenylamine
615-43-0

2-iodophenylamine

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / dimethyl sulfoxide / 16 h / 45 °C / Schlenk technique; Inert atmosphere
2.1: pyridine / dichloromethane / 12 h / 0 - 20 °C / Schlenk technique; Inert atmosphere
3.1: diethylzinc / toluene; dimethyl sulfoxide / 10 h / 25 °C / 760.05 Torr / Schlenk technique
3.2: 3 h / 0 - 20 °C / Schlenk technique; Inert atmosphere
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / Schlenk technique; Reflux
5.1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C / Schlenk technique
6.1: sodium anthracenide / 1,2-dimethoxyethane / 1 h / -78 °C / Schlenk technique; Inert atmosphere
View Scheme
C19H18N2O3S

C19H18N2O3S

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

Conditions
ConditionsYield
With sodium anthracenide In 1,2-dimethoxyethane at -78℃; for 1h; Schlenk technique; Inert atmosphere;4.6437 g
2-allyl-phenylamine
32704-22-6

2-allyl-phenylamine

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: pyridine / dichloromethane / 20 °C
2.1: dichloro[2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]palladium(II); silver trifluoromethanesulfonate / toluene / 12 h / 90 °C / Inert atmosphere
3.1: potassium hydroxide / ethanol / 80 °C / Schlenk technique; Inert atmosphere
4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Schlenk technique; Inert atmosphere
4.2: 0 °C / Schlenk technique; Inert atmosphere
5.1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 24 h / 20 °C / 3800.26 Torr / Autoclave
6.1: triethylamine / dichloromethane / 20 °C / Schlenk technique
7.1: boron trifluoride diethyl etherate / toluene / 110 °C / Inert atmosphere
View Scheme
N,N-dibenzyl-2-(1-tosyl-1H-indol-2-yl)ethan-1-amine

N,N-dibenzyl-2-(1-tosyl-1H-indol-2-yl)ethan-1-amine

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium hydroxide / ethanol / 80 °C / Schlenk technique; Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Schlenk technique; Inert atmosphere
2.2: 0 °C / Schlenk technique; Inert atmosphere
3.1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 24 h / 20 °C / 3800.26 Torr / Autoclave
4.1: triethylamine / dichloromethane / 20 °C / Schlenk technique
5.1: boron trifluoride diethyl etherate / toluene / 110 °C / Inert atmosphere
View Scheme
N-tosyl-o-allylaniline
51315-69-6

N-tosyl-o-allylaniline

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: dichloro[2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]palladium(II); silver trifluoromethanesulfonate / toluene / 12 h / 90 °C / Inert atmosphere
2.1: potassium hydroxide / ethanol / 80 °C / Schlenk technique; Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Schlenk technique; Inert atmosphere
3.2: 0 °C / Schlenk technique; Inert atmosphere
4.1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 24 h / 20 °C / 3800.26 Torr / Autoclave
5.1: triethylamine / dichloromethane / 20 °C / Schlenk technique
6.1: boron trifluoride diethyl etherate / toluene / 110 °C / Inert atmosphere
View Scheme
N,N-dibenzyl-2-(1H-indol-2-yl)ethanamine

N,N-dibenzyl-2-(1H-indol-2-yl)ethanamine

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Schlenk technique; Inert atmosphere
1.2: 0 °C / Schlenk technique; Inert atmosphere
2.1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 24 h / 20 °C / 3800.26 Torr / Autoclave
3.1: triethylamine / dichloromethane / 20 °C / Schlenk technique
4.1: boron trifluoride diethyl etherate / toluene / 110 °C / Inert atmosphere
View Scheme
C25H26N2

C25H26N2

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 24 h / 20 °C / 3800.26 Torr / Autoclave
2: triethylamine / dichloromethane / 20 °C / Schlenk technique
3: boron trifluoride diethyl etherate / toluene / 110 °C / Inert atmosphere
View Scheme
2-(1-methyl-indol-2-yl)-ethylamine
7088-88-2

2-(1-methyl-indol-2-yl)-ethylamine

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 20 °C / Schlenk technique
2: boron trifluoride diethyl etherate / toluene / 110 °C / Inert atmosphere
View Scheme
<5-13C>methyl-(3H-imidazol-<4-13C>yl)-methanol

<5-13C>methyl-(3H-imidazol-<4-13C>yl)-methanol

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

2,3,4,5-tetrahydro-5-methyl-2-<(<5-13C>methyl-1H-imidazol-<4-13C>yl)methyl>-1H-pyrido<4,3-b>indol-1-one

2,3,4,5-tetrahydro-5-methyl-2-<(<5-13C>methyl-1H-imidazol-<4-13C>yl)methyl>-1H-pyrido<4,3-b>indol-1-one

Conditions
ConditionsYield
With methanesulfonic acid In various solvent(s) at 135℃; for 4h;74%
N3-BOC-5-(hydroxymethyl)-4-methylimidazole
550340-81-3

N3-BOC-5-(hydroxymethyl)-4-methylimidazole

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

alosetron
122852-42-0

alosetron

Conditions
ConditionsYield
Stage #1: N3-BOC-5-(hydroxymethyl)-4-methylimidazole; 2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one With trifluoroacetic acid In N,N-dimethyl-formamide at 100 - 115℃;
Stage #2: With potassium carbonate In water pH=6.8 - 7; Product distribution / selectivity;
65%
2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

5-methyl-(3H-imidazol-4-yl)-<2H2>methanol

5-methyl-(3H-imidazol-4-yl)-<2H2>methanol

5-methyl-2-(5-methyl-1H-imidazol-4-yl-<2H2>methyl)-2,3,4,5-tetrahydro-pyrido<4,3-b>indol-1-one

5-methyl-2-(5-methyl-1H-imidazol-4-yl-<2H2>methyl)-2,3,4,5-tetrahydro-pyrido<4,3-b>indol-1-one

Conditions
ConditionsYield
With methanesulfonic acid In various solvent(s) at 135℃; for 4h;62%
2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

4(5)-methyl-5(4)-hydroxymethylimidazole
29636-87-1

4(5)-methyl-5(4)-hydroxymethylimidazole

alosetron
122852-42-0

alosetron

Conditions
ConditionsYield
With methanesulfonic acid In 1-methyl-pyrrolidin-2-one at 20 - 135℃; for 21h; Schlenk technique; Inert atmosphere;58%
2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

(<5-13C2H3>methyl-3H-imidazol-4-yl)-methanol

(<5-13C2H3>methyl-3H-imidazol-4-yl)-methanol

5-methyl-2-(<<5-13C2H3>methyl-1H-imidazol-4-yl>methyl)-2,3,4,5-tetrahydropyrido<4,3-b>indol-1-one

5-methyl-2-(<<5-13C2H3>methyl-1H-imidazol-4-yl>methyl)-2,3,4,5-tetrahydropyrido<4,3-b>indol-1-one

Conditions
ConditionsYield
With methanesulfonic acid In various solvent(s) at 135℃; for 4h;52%
4-hydroxymethyl-5-methylimidazole hydrochloride
38585-62-5

4-hydroxymethyl-5-methylimidazole hydrochloride

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

alosetron
122852-42-0

alosetron

Conditions
ConditionsYield
In 1-methyl-pyrrolidin-2-one at 140℃; for 4h; Inert atmosphere;29%
maleic acid
110-16-7

maleic acid

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-6-(phenylmethoxy)-1H-pyrido[4,3-b]indol-1-one maleate
128486-73-7

2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-6-(phenylmethoxy)-1H-pyrido[4,3-b]indol-1-one maleate

4-hydroxymethyl-5-methylimidazole hydrochloride
38585-62-5

4-hydroxymethyl-5-methylimidazole hydrochloride

sodium hydrogencarbonate
144-55-8

sodium hydrogencarbonate

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

alosetron
122852-42-0

alosetron

Conditions
ConditionsYield
With p-toluenesulfonic acid monohydrate In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane
In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane
4-chloromethyl-5-methyl-1-tritylimidazole
106147-85-7

4-chloromethyl-5-methyl-1-tritylimidazole

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

alosetron
122852-42-0

alosetron

Conditions
ConditionsYield
With hydrogenchloride In 1,2-dimethoxyethane; water
With hydrogenchloride In 1,2-dimethoxyethane; water
With hydrogenchloride In 1,2-dimethoxyethane; water
1-(chloromethyl)-2-methyl-1H-imidazole hydrochloride

1-(chloromethyl)-2-methyl-1H-imidazole hydrochloride

maleic acid
110-16-7

maleic acid

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

2,3,4,5-Tetrahydro-5-methyl-2-[(2-methyl-1H-imidazol-1yl)methyl]-1H-pyrido[4,3-b]indol-1-one maleate
126770-17-0

2,3,4,5-Tetrahydro-5-methyl-2-[(2-methyl-1H-imidazol-1yl)methyl]-1H-pyrido[4,3-b]indol-1-one maleate

Conditions
ConditionsYield
In ethanol; N,N-dimethyl-formamide
N3-BOC-5-(hydroxymethyl)-4-methylimidazole
550340-81-3

N3-BOC-5-(hydroxymethyl)-4-methylimidazole

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one
122852-75-9

2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one

2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one hydrochloride

2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: trifluoroacetic acid / N,N-dimethyl-formamide / 100 - 115 °C
1.2: pH 6.8 - 7
2.1: hydrogenchloride / isopropyl alcohol; methanol / 40 - 45 °C
View Scheme

122852-75-9Relevant articles and documents

Palladium-Catalyzed Dehydrogenative Difunctionalization of Aminoalkenes with Aminals as Oxidants and Electrophiles

Li, Lixin,Zhou, Xibing,Yu, Bangkui,Huang, Hanmin

supporting information, p. 4600 - 4603 (2017/09/12)

A novel palladium-catalyzed aminomethylamination of aminoalkenes with an aminal, functioning not only as an aminomethylation reagent but also as an oxidant, was developed. This direct and operationally simple protocol provides a fundamentally novel and unique approach toward the synthesis of 2-(2-aminoethyl)indoles and 2-(2-aminoethyl)pyrrolidines, which are important building blocks in synthetic organic chemistry. The unity of this method was highlighted by the rapid synthesis of Alosetron, a drug used for the treatment of irritable bowel syndrome.

INDOLONE MODULATORS OF 5-HT3 RECEPTOR

-

Page/Page column 12, (2010/05/13)

The present invention relates to new indolone modulators of 5-HT3 receptor, pharmaceutical compositions thereof, and methods of use thereof.

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