128496-42-4

Upstream product

• 95334-98-8 C₂₆H₁₉BO₈ 
• 62-53-3 aniline 
• 107022-84-4 (2S,4S)-(+)-2-(tert-butyldimethylsilyloxy)methyl-2,4,5,12-tetrahydroxy-1,2,3,4-tetrahydronaphthacene-6,11-dione 
• 107022-83-3 (R)-2-(tert-butyldimethylsilyloxymethyl)-2,5,12-trihydroxy-1,2,3,4-tetrahydronaphthacene-6,11-dione 
• 90146-19-3 (2R)-methyl 1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-6,11-dioxonaphthacene-2-carboxylate 
• 103-71-9 phenyl isocyanate 
• 91593-24-7 (+)-(1S,3S)-1,2,3,4,6,11-hexahydro-1,3,5,12-tetrahydroxy-3-(hydroxymethyl)-6,11-naphthacenedione 

Relevant academic research and scientific papers

Novel Syntheses of Optically Active 4-Demethoxyanthracyclinones Carrying a Hydroxymethyl or a Carbamoyloxymethyl Group at the C9-Position

The title compounds were effectively synthesized by chemoselective reduction of (R)-methyl 2,5,12-trihydroxy-6,11-dioxo-1,2,3,4-tetrahydronaphthacene-2-carboxylate to the corresponding (R)-alcohol with lithium tri-t-butoxyaluminium hydride, followed by stereoselective C7α-hydroxylation (the anthracycline numbering) and urethane formation.

Synthesis and antitumor activity of novel 4-demethoxyanthracyclines

A versatile and efficient synthetic route to 4-demethoxyanthracyclinones has been utilized in the preparation of a number of aglycons having 9-alkyl, 9-(hydroxylalkyl), or 9-carbamoyl substituents. Silver trifluoromethanesulfonate catalyzed coupling of th