128510-83-8

Upstream product

• 111604-99-0 [1-(4-Methoxyphenyl)-2-[2-nitro-6-(trifluoromethyl)phenyl]ethyl]propanedioic acid,dimethyl ester 
• 138573-29-2 2-[1-(4-Methoxy-phenyl)-2-(2-nitro-6-trifluoromethyl-phenyl)-ethyl]-2-methyl-malonic acid dimethyl ester 
• 111605-18-6 (3S,4R)-4-(4-Methoxy-phenyl)-3-methyl-2-oxo-6-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepine-3-carboxylic acid methyl ester 
• 111605-09-5 (3S,4S-trans)-1,3,4,5-tetrahydro-6-(trifluoromethyl)-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 111605-10-8 (3S,4S)-1,3,4,5-tetrahydro-3-(methoxycarbonyl)-1-(methoxymethyl)-4-(4-methoxyphenyl)-6-(trifluoromethyl)-2H-1-benzazepin-2-one 
• 111605-17-5 <3S-(3α,3β,4β)>-1,3,4,5-tetrahydro-3-(methoxycarbonyl)-1-(methoxymethyl)-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-benzazepin-2-one 
• 138663-28-2 <3S-(3α,3β,4β)>-1,3,4,5-tetrahydro-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-benzazepin-2-one 
• 138573-41-8 2-[2-(2-Amino-6-trifluoromethyl-phenyl)-1-(4-methoxy-phenyl)-ethyl]-2-methyl-malonic acid dimethyl ester 
• 7443-25-6 dimethyl 2-(4-methoxybenzylidene)malonate 
• 6656-49-1 2-methyl-1-nitro-3-(trifluoromethyl)benzene 
• 111605-18-6 (3S,4S)-4-(4-Methoxy-phenyl)-3-methyl-2-oxo-6-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepine-3-carboxylic acid methyl ester 

Downstream Products

• 128573-80-8 cis-1,3,4,5-tetrahydro-3-methyl-6-(trifluoromethyl)-1-<2-(dimethylamino)propyl>-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 138335-61-2 (3S,4S)-1-(3-Dimethylamino-propyl)-4-(4-methoxy-phenyl)-3-methyl-6-trifluoromethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 
• 138335-59-8 (3S,4S)-1-[2-(Isopropyl-methyl-amino)-ethyl]-4-(4-methoxy-phenyl)-3-methyl-6-trifluoromethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 
• 119217-19-5 (3S,4S)-1-(2-Diisopropylamino-ethyl)-4-(4-methoxy-phenyl)-3-methyl-6-trifluoromethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 
• 111604-76-3 trans-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-1-benzazepin-2-one 
• 111604-76-3 (3S,4R)-1-(2-Dimethylamino-ethyl)-4-(4-methoxy-phenyl)-3-methyl-6-trifluoromethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 
• 111604-76-3 (3R,4R)-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-3-methyl-6-(trifluoromethyl)-2H-benzazepin-2-one 
• 138335-21-4 (3S,4S)-1-(2-Dimethylamino-ethyl)-4-(4-methoxy-phenyl)-3-methyl-6-trifluoromethyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 

Relevant academic research and scientific papers

Benzazepinone Calcium Channel Blockers. 3. Synthesis and Structure-Activity Studies of 3-Alkylbenzazepinones

As part of a program aimed at identifying novel analogues of diltiazem, we developed several synthetic routes for 3-alkylbenzazepinones, both in racemic and nonracemic form.Structure-activity relationship studies in this series have led to identification

Benzazepinone calcium channel blockers. 4. Structure-activity overview and intracellular binding site

We have synthesized a series of benzazepinones (2) in order to determine the structure-activity relationships (SAR) for calcium channel blockers related to diltiazem. A prerequisite for calcium channel blocking activity in vitro and in vivo is the presenc