128531-59-9

Basic information

• Product Name: L-gamma-glutamyl-3-[(diethylcarbamothioyl)disulfanyl]-L-alanylglycine
• CAS NO: 128531-59-9
• Molecular Formula: C₁₅H₂₆N₄O₆S₃
• Molecular Weight: 454.5851
• Mol File: 128531-59-9.mol
• Article Data: 1

Chemical Properties

• Density: 1.412g/cm³
• Refractive Index: 1.615
• CAS DataBase Reference: L-gamma-glutamyl-3-[(diethylcarbamothioyl)disulfanyl]-L-alanylglycine(CAS DataBase Reference)
• NIST Chemistry Reference: L-gamma-glutamyl-3-[(diethylcarbamothioyl)disulfanyl]-L-alanylglycine(128531-59-9)
• EPA Substance Registry System: L-gamma-glutamyl-3-[(diethylcarbamothioyl)disulfanyl]-L-alanylglycine(128531-59-9)

Safety Data

• Hazardous Substances Data: 128531-59-9(Hazardous Substances Data)

Upstream product

• 27025-41-8 Oxidized glutathione 
• 6384-93-6 (S)-2-Amino-4-[(R)-2-[(R)-2-((S)-4-amino-4-carboxy-butyrylamino)-2-(carboxymethyl-carbamoyl)-ethylsulfanylthiosulfonyl]-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid 
• 148-18-5 sodium N,N-diethyldithiocarbamate 

Relevant articles and documents

New mixed disulfides of L-cysteine derivatives and of glutathione with diethyldithiocarbamic acid and 2-mercaptoethanesulfonic acid

It is generally assumed that thiol anticarcinogens like disulfiram (DSF) or sodium 2-mercaptoethane-sulfonate (mesna) after in vivo administration react rapidly with serum protein sulfhydryl groups forming mixed disulfides. Different methods have been established for the synthesis of mixed disulfides between cysteine or glutathione and diethyldithiocarbamate (DDTC) or mesna in order to elucidate their chemical and biological effects. A short summary is given of pilot biochemical experiments carried out with two mixed disulfides.