1285511-99-0Relevant articles and documents
Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist
Spetea, Mariana,Berzetei-Gurske, Ilona P.,Guerrieri, Elena,Schmidhammer, Helmut
supporting information, p. 10302 - 10306 (2013/01/16)
Here we report on the design, synthesis, and biological characterization of novel κ opioid (KOP) receptor ligands of diphenethylamines. In opioid receptor binding and functional assays, the N-cyclobutylmethyl substituted derivative 4 (HS665) showed the hi