1285527-15-2

Basic information

• Product Name: neamine 6'-N-(R)-(3-((2-((2-amino-2-oxoethyl)thio)ethyl)amino)-3-oxopropyl)-2-hydroxy-3,3-dimethyl-4-(3-oxo-N-phenethylbutanamido)butanamide
• CAS NO: 1285527-15-2
• Molecular Weight: 827.997
• Mol File: 1285527-15-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: neamine 6'-N-(R)-(3-((2-((2-amino-2-oxoethyl)thio)ethyl)amino)-3-oxopropyl)-2-hydroxy-3,3-dimethyl-4-(3-oxo-N-phenethylbutanamido)butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: neamine 6'-N-(R)-(3-((2-((2-amino-2-oxoethyl)thio)ethyl)amino)-3-oxopropyl)-2-hydroxy-3,3-dimethyl-4-(3-oxo-N-phenethylbutanamido)butanamide(1285527-15-2)
• EPA Substance Registry System: neamine 6'-N-(R)-(3-((2-((2-amino-2-oxoethyl)thio)ethyl)amino)-3-oxopropyl)-2-hydroxy-3,3-dimethyl-4-(3-oxo-N-phenethylbutanamido)butanamide(1285527-15-2)

Safety Data

• Hazardous Substances Data: 1285527-15-2(Hazardous Substances Data)

Upstream product

• 1285527-18-5 (2R,2'R)-N,N'-(((disulfanediylbis(ethane-2,1-diyl))bis(azanediyl))bis(3-oxopropane-3,1-diyl))bis(2-((tert-butyldimethylsilyl)oxy)-4-hydroxy-3,3-dimethylbutanamide) 
• 1285527-19-6 C₃₄H₆₆N₄O₈S₂Si₂ 
• 220874-82-8 N-6'-bromoacetylneamine 
• 1285527-17-4 C₄₆H₉₈N₄O₈S₂Si₄ 
• 138148-35-3 D-pantethine 

Relevant articles and documents

Synthesis of 4′-aminopantetheine and derivatives to probe aminoglycoside N-6′-acetyltransferase

A convenient synthesis of 4′-aminopantetheine from commercial d-pantethine is reported. The amino group was introduced by reductive amination in order to avoid substitution at a sterically congested position. Derivatives of 4′-aminopantetheine were also prepared to evaluate the effect of O-to-N substitution on inhibitors of the resistance-causing enzyme aminoglycoside N-6′-acetyltransferase. The biological results combined with docking studies indicate that in spite of its reported unusual flexibility and ability to adopt different folds, this enzyme is highly specific for AcCoA. The Royal Society of Chemistry 2011.