1285533-99-4

Upstream product

• 220000-87-3 4-chloro-N-methylpicolinamide 
• 100-01-6 4-nitro-aniline 
• 123-30-8 4-amino-phenol 
• 51727-15-2 4-chloro-2-pyridine carboxylic acid chloride hydrochloride 
• 284462-37-9 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide 
• 100-28-7 4-Nitrophenyl isocyanate 
• 98-98-6 2-Picolinic acid 
• 6465-01-6 (4-nitrophenyl)carbamic acid phenyl ester 

Relevant academic research and scientific papers

Convenient synthesis of sorafenib and its derivatives

This article describes a convenient synthesis of sorafinib and its derivatives from phenyl carbamates in good yields. This procedure, avoiding toxic phosgene, is especially suitable for large-scale preparation. Copyright

Synthesis of aryl urea derivatives from aryl amines and aryl isocyanates

The present study describes the synthesis of novel diaryl urea derivatives derived from aryl amine and aryl isocyanates. The synthesized compounds are analogs of sorafenib [4-[4-[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl] amino]phenoxy]-N-methylpyridine-2- carboxamide] having potential antiproliferative activity.