1285534-80-6

Upstream product

• 1620124-63-1 C₂₄H₄₃N₃O₈Si₂ 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 1620124-66-4 C₁₂H₁₇N₃O₇ 
• 86988-35-4 3-benzoyl-1-[(6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]pyrimidine-2,4(1H,3H)-dione 
• 949158-27-4 2'-O-[2-(methoxycarbonyl)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 949158-26-3 N₃-benzoyl-2'-O-(2-methoxycarbonylethyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 1285534-78-2 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(methoxycarbonyl)ethyl]uridine 
• 949158-30-9 2'-O-[2-(methoxycarbonyl)ethyl]uridine 

Downstream Products

• 1620124-71-1 5′-O-(4,4′-dimethoxytrityl)-2′-O-(2-carbamoylethyl)uridine 3′-(2-cyanoethyl N,N-diisopropylphosphoramidite) 

Relevant academic research and scientific papers

Synthesis and properties of oligonucleotides modified with 2′-O-(2-carboxyethyl)nucleotides and their carbamoyl derivatives

2′-O-Methyl oligoribonucleotides with four kinds of 2′-O-modified uridine derivatives were synthesised. Their duplex stability, hydration behavior and exonuclease resistance were studied by spectroscopic analyses and molecular dynamics simulations. Conseq

Synthesis of 2′-O-[2-(N-methylcarbamoyl)ethyl]ribonucleosides using oxa-michael reaction and chemical and biological properties of oligonucleotide derivatives incorporating these modified ribonucleosides

To develop oligonucleotides containing new 2′-O-modified ribonucleosides as nucleic acid drugs, we synthesized three types of ribonucleoside derivatives modified at the 2′-hydroxyl group with 2-(methoxycarbonyl)ethyl (MOCE), 2-(N-methylcarbamoyl)ethyl (MC