86988-35-4

Upstream product

• 58-96-8 uridine 
• 119694-66-5 4-O-<(2,4,6-triisopropylphenyl)sulfonyl>-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 69304-38-7 3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 415903-48-9 3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-2'-O-(trimethylsilyl)uridine 
• 69304-37-6 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1207847-50-4 N₃-benzoyl-2'-O-methoxycarbonylmethyl-1',3'-O-(1,1,3,3-tetraisopropyldisiloxane)uridine 
• 1620124-67-5 5′-O-(4,4′-dimethoxytrityl)-2′-O-[2-(N-phenylcarbamoyl)ethyl]uridine 
• 1620124-65-3 N³-benzoyl-2′-O-(2-methoxycarbonylethyl)uridine 
• 1620124-64-2 2′-O-[2-(N-phenylcarbamoyl)ethyl]-3′,5′-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 1620124-72-2 5′-O-(4,4′-dimethoxytrityl)-2′-O-[2-(N-phenylcarbamoyl)ethyl]uridine 3′-(2-cyanoethyl N,N-diisopropylphosphoramidite) 
• 1620124-71-1 5′-O-(4,4′-dimethoxytrityl)-2′-O-(2-carbamoylethyl)uridine 3′-(2-cyanoethyl N,N-diisopropylphosphoramidite) 
• 2140-76-3 2'-O-methyluridine 
• 1360744-36-0 2'-O-(N,N'-di-Boc-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-uridine 3'-(cyanoethyl)-N,N-diisopropyl phosphoramidite 
• 1360744-35-9 2'-O-(N,N'-di-Boc-guanidinopropyl)-5'-O-(4,4'-dimethoxytrityl)-uridine 
• 1285534-76-0 N₃-benzoyl-2'-O-(2-ethoxycarbonylethyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 949158-34-3 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N-methylcarbamoyl)ethyl]uridine 3'-(2-cyanoethyl-N,N-diisopropylphosphoramidite) 
• 1285534-80-6 5′-O-(4,4′-dimethoxytrityl)-2′-O-(2-carbamoylethyl)uridine 
• 1285534-79-3 C₃₃H₃₄N₂O₁₀ 
• 949158-38-7 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N,N-dimethylcarbamoyl)ethyl]uridine 

Relevant academic research and scientific papers

Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides

Seventeen silyl- and trityl-modified (5′-O- and 3′,5′-di-O-) nucleosides were synthesized with the aim of investigating the in vitro antiproliferative activities of these nucleoside derivatives. A subset of the compounds was evaluated at a fixed concentra

A New Microfluidic Phase-Transfer Reaction Using HPLC Guard Columns as the Reactor for the N3-Protection of Uridine Derivatives

N3-Acylation of uridine derivatives with acyl chlorides, mediated by a phase-transfer reaction, was studied using a new microfluidic device containing an HPLC guard as an effective reactor. The acylated products were obtained in more than 80% y

An improved transient method for the synthesis of N-benzoylated nucleosides

The Jones' transient method for the synthesis of N-benzoylated nucleosides is improved by reducing the amounts of chlorotrimethylsilane (TMSCl) and benzoyl chloride to nearly equivalent quantities. The easy work-up and high yields of products are the major advantages of this approach. Jones' method is further simplified by omitting the addition of ammonium hydroxide. The utility of this modification for the preparation of some useful protected nucleosides is also presented.

Efficient large scale synthesis of 2′-O-alkyl pyrimidine ribonucleosides

An efficient process to synthesize 2′-O-alkyl pyrimidine ribonucleosides in high yield has been described. The inexpensive method was used on a multikilogram-scale synthesis and optimized reaction conditions have been investigated.

Nucleosides and nucleotides. 95. Improved synthesis of 1-(2-azido-2-deoxy-β-D-arabinofuranosyl)cytosine (cytarazid) and -thymine. Inhibitory spectrum of cytarazid on the growth of various human tumor cells in vitro

Reaction of N3-benzoyl-1-[3,5-O-(tetraisopropyldisiloxan-1,3-diyl)- β-D-ribofuranosyl]thymine (4a) with diphenyl phosphorazidate, diethyl azodicarboxylate, and triphenylphosphine in tetrahydrofuran afforded N3-benzoyl-1-[2-azido-2-de

General Method for the Preparation of N3- and O4-Substituted Uridine Derivatives by Phase-Transfer Reactions

A general method for regioselective introduction of a variety of protecting groups into the uracil residue of 1 has been developed by use of the phase-transfer reaction.Under such conditions, acyl groups such as benzoyl, p-toluyl, p-anisoyl, (2,2,2-trichl