1285538-65-9Relevant academic research and scientific papers
Hypervalent organochalcogenanes as inhibitors of protein tyrosine phosphatases
Piovan, Leandro,Wu, Li,Zhang, Zhong-Yin,Andrade, Leandro H.
, p. 1347 - 1351 (2011/04/16)
A series of organochalcogenanes was synthesized and evaluated as protein tyrosine phosphatases (PTPs) inhibitors. The results indicate that organochalcogenanes inactivate the PTPs in a time- and concentration-dependent fashion, most likely through covalent modification of the active site sulfur-moiety by the chalcogen atom. Consequently, organochalcogenanes represent a new class of mechanism-based probes to modulate the PTP-mediated cellular processes. The Royal Society of Chemistry 2011.
