1285553-17-4Relevant academic research and scientific papers
Method for alpha-position methylation of aryl benzyl sulfone compound
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Paragraph 0045-0049, (2020/11/23)
The invention discloses a method for alpha-position methylation of an aryl benzyl sulfone compound. The method comprises the following steps: sequentially adding the aryl benzyl sulfone compound, methanol, a metal precursor M, a ligand L, an alkaline substance and a solvent into a reactor, carrying out heating to 110-150 DEG C under the protection of nitrogen, conducting reacting for 20-30 hours,performing cooling to room temperature, conducting concentrating under reduced pressure, recovering the solvent and redundant methanol, and carrying out column chromatographic separation on residues to obtain the alpha-methylated aryl sulfone compound as shown in a formula (I). The method provided by the invention has the characteristics of easily available raw materials, simple operation, high chemical selectivity and regioselectivity and the like, meets the requirements of green chemistry, and has great implementation value and social and economic benefits.
Iron(III) phthalocyanine-chloride-catalyzed synthesis of sulfones from sulfonylhydrazones
Zhao, Jun-Long,Guo, Shi-Huan,Qiu, Jun,Gou, Xiao-Feng,Hua, Cheng-Wen,Chen, Bang
supporting information, p. 2375 - 2378 (2016/05/19)
In this study, sulfones are synthesized from sulfonylhydrazones catalyzed by iron(III) phthalocyanine chloride. This reaction offers broad substrate scope, occurs under mild conditions, utilized readily available reactants, and forms products in good-to-h
Synthesis of sulfones by iron-catalyzed decomposition of sulfonylhydrazones
Barluenga, Jose,Tomas-Gamasa, Maria,Aznar, Fernando,Valdes, Carlos
experimental part, p. 1520 - 1526 (2011/04/25)
The Fe-catalyzed decomposition of sulfonylhydrazones gives rise to sulfones. The reaction is quite general and allows the preparation of sulfones from a variety of aryl, alkyl, and α,β-unsaturated aldehydes and ketones. Crossover experiments reveal that the reaction is an intermolecular process, which may proceed by nucleophilic attack of the sulfinate anion on an iron carbene complex. Carbonyl compounds can be easily transformed into sulfones by Fe-catalyzed decomposition of the corresponding sulfonylhydrazones. The process most likely proceeds through an iron carbene complex and opens the door for the design of othernovel Fe-catalyzed reductive couplings. Copyright
