50626-29-4Relevant academic research and scientific papers
Base-Promoted Direct Synthesis of Sulfinates from N -Sulfonyl-hydrazones under Metal-Free Conditions
Ji, Yuan-Zhao,Li, Hui-Jing,Luo, Dong-Hui,Wu, Qin-Xi,Wu, Yan-Chao
, p. 755 - 762 (2020/02/25)
A base-promoted direct synthesis of sulfinates from N -sulfonylhydrazones is described. Various N -sulfonylhydrazones, derived from aldehydes and ketones, are converted into the corresponding sulfinates in moderate to good yields. This protocol possesses
Structure activity relationships, multidrug resistance reversal and selectivity of heteroarylphenyl ABCG2 inhibitors
K?hler, Sebastian C.,Vahdati, Sahel,Scholz, Matthias S.,Wiese, Michael
, p. 483 - 500 (2018/02/14)
An overexpression of the transmembrane ATP-binding cassette transporter G2 (ABCG2, BCRP) in cancer tissues is supposed to play a role in the multidrug resistance (MDR) of tumors resulting in an inefficient chemotherapy. Therefore, co-administration of sel
Synthesis, biological evaluation and molecular docking of new benzenesulfonylhydrazone as potential anti-trypanosoma cruzi agents
Elizondo-Jimenez, Silvia,Moreno-Herrera, Antonio,Reyes-Olivares, Rogelio,DorantesGonzalez, Edith,Nogueda-Torres, Benjamín,De Oliveira, Eduardo Alves Gamosa,Romeiro, Nelilma C.,Lima, Lídia Moreira,Palos, Isidro,Rivera, Gildardo
, p. 149 - 158 (2017/02/05)
Background: Chagas disease is a public health problem caused by Trypanosoma cruzi. Cruzain is a pharmacological target for designing a new drug against this parasite. Hydrazone and N-acylhydrazone derivatives have been traditionally associated as potentia
Iron(III) phthalocyanine-chloride-catalyzed synthesis of sulfones from sulfonylhydrazones
Zhao, Jun-Long,Guo, Shi-Huan,Qiu, Jun,Gou, Xiao-Feng,Hua, Cheng-Wen,Chen, Bang
supporting information, p. 2375 - 2378 (2016/05/19)
In this study, sulfones are synthesized from sulfonylhydrazones catalyzed by iron(III) phthalocyanine chloride. This reaction offers broad substrate scope, occurs under mild conditions, utilized readily available reactants, and forms products in good-to-h
Tandem reaction of propargyl alcohol and N-sulfonylhydrazone: Synthesis of dihydropyrazole and its utility in the preparation of 3,3-diarylacrylonitrile
Zhu, Yuanxun,Wen, Shan,Yin, Guangwei,Hong, Deng,Lu, Ping,Wang, Yanguang
supporting information; experimental part, p. 3553 - 3555 (2011/09/14)
An efficient and straightforward strategy for the synthesis of 4-methylene-1-(phenylsulfonyl)-4,5-dihydro-1H-pyrazole from propargyl alcohol and N-sulfonylhydrazone is described. N-Sulfonyl allenamide is postulated to be the key intermediate for this tandem transformation.
Relationship between structure and antineoplastic activity of (arylsulfonyl)hydrazones of 4-pyridinecarboxaldehyde
Shyam,Cosby,Sartorelli
, p. 149 - 152 (2007/10/02)
The effects of various structural modifications on the antineoplastic activity of (arylsulfonyl)hydrazones of 4-pyridinecarboxaldehyde were examined in mice bearing either Sarcoma 180 or P388 leukemia. The introduction of different functional groups into
