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Usage

Uses

Used in Pharmaceutical Research:
4-(TRIFLUOROMETHYL)-1H-INDOLE is used as a valuable candidate in pharmaceutical research for its potential therapeutic applications in various diseases. Its unique chemical structure and fluorine substitution allow it to modulate the activity of biological targets effectively.
Used in Drug Development:
In the field of drug development, 4-(TRIFLUOROMETHYL)-1H-INDOLE is utilized as a promising compound due to its demonstrated biological activities, including anti-inflammatory and anti-cancer properties. These properties make it a potential candidate for the development of new therapeutic agents.
Used in Medicinal Chemistry:
4-(TRIFLUOROMETHYL)-1H-INDOLE serves as a versatile building block in medicinal chemistry for the synthesis of complex molecules. Its trifluoromethyl group contributes to the compound's overall stability and lipophilicity, which are essential for the design and development of novel pharmaceuticals.
Used in Biological Target Modulation:
In the context of biological target modulation, 4-(TRIFLUOROMETHYL)-1H-INDOLE is employed for its ability to interact with and modulate the activity of various biological targets. This makes it a useful tool in understanding the mechanisms of action and potential therapeutic effects of the compound in different disease conditions.

InChI:InChI=1/C9H6F3N/c10-9(11,12)7-2-1-3-8-6(7)4-5-13-8/h1-5,13H

Upstream product

• 6656-49-1 2-methyl-1-nitro-3-(trifluoromethyl)benzene 
• 905274-06-8 dimethyl[(E)-2-(2-nitro-6-trifluoromethylphenyl)vinyl]amine 

Downstream Products

• 1018974-87-2 1-benzenesulfonyl-4-trifluoromethyl-1H-indole 
• 1018974-88-3 1-benzenesulfonyl-2-methyl-4-trifluoromethyl-1H-indole 
• 1313040-69-5 [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indol-3-yl]-methanone hydrochloride 
• 1313043-33-2 2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indole-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide 
• 1313043-31-0 2,2,2-trifluoro-1-(1-(2-methoxyethyl)-4-(trifluoromethyl)-1H-indol-3-yl)ethanone 

Relevant academic research and scientific papers

A indole compound and its preparation method and application (by machine translation)

The invention discloses a indole compound and its preparation method and application. The indole compounds of the structural formula such as formula (I) is shown. The indoles, rice galenical demonstrate the excellent inhibitory activity, the effect of most of the compound is obviously better than the positive control drug validamycin; especially compound I - 43, I - 44, I - 54, I - 73, II - 7 and II - 17, its galenical very good living body protection and treating effect, effect is better than the positive control; more specifically, compound I - 43 of the rice sheath blight bacteriostatic activity than validamycin activity is improved by nearly 300 times. The indole compounds in the prevention and/or treatment of rice sheath blight has great application prospects. In addition the compound of the invention is simple in construction, the preparation method is simple, and is suitable for large-scale industrial production. (I). (by machine translation)

QUINUCLIDINES FOR MODULATING ALPHA 7 ACTIVITY

Provided are substituted quinuclidine compounds, pharmaceutical compositions comprising such compounds, and methods of modulating α7 nicotinic acetylcholine receptors and treating neurological disorders using such compounds.

HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS

The invention relates to heterocyclic compounds and their use as antibiotics and/or as antibiotic potentiators. The compounds may act as colistin potentiators and SOS inhibitors.

NOVEL PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS

The present invention relates to novel chemical compounds derived from pyrimidines, to the method for preparing same, to the novel intermediates obtained, to the use thereof as drugs, to the pharmaceutical compositions containing same, and to the therapeutic use thereof as AKT inhibitors.

INDOLE SULFONAMIDES AS SFRP-1 MODULATORS

Indole sulfonamide compounds or pharmaceutically acceptable salts thereof, are provided, which are modulators of secreted frizzled related protein-1. The compounds, and compositions containing the compounds, can be used to treat a variety of disorders, in

Synthesis and biological activities of 4-trifluoromethylindole-3-acetic acid: A new fluorinated indole auxin

In our studies on the development of new promoters for the root formation of tree cuttings, 4-trifluoromethylindole-3-acetic acid (4-CF3-IAA), a new fluorinated auxin, was synthesized via 4-trifluoromethylindole and 4-trifluoromethylindole-3-acetonitrile by using 2-methyl-3-nitrobenzotrifluoride as the starting material. As a control compound for comparing biological activities, 4-methylindole-3-acetic acid (4-CH3-IAA) was also synthesized by using 2,3-dimethylnitrobenzene as the starting material. The biological activities of these compounds were compared by three bioassays with those of indole-3-acetic acid and 4-chloroindole-3-acetic acid (4-Cl-IAA), which, like 4-CF3-IAA and 4-CH3-IAA, has a substituent at the 4-position of the indole nucleus. 4-CF3-IAA showed strong root formation-promoting activity with black gram cuttings which was 1.5 times higher than that of 4-(3-indole)butyric acid at 1 × 10-4 M. 4-CH 3-IAA, however, only weakly promoted root formation in spite of its strong inhibition of hypocotyl growth in Chinese cabbage and promotion of hypocotyl swelling and lateral root formation in black gram. On the other hand, 4-CF3-IAA demonstrated weaker activities than 4-CH3-IAA and 4-Cl-IAA in these two bioassays.