1313043-33-2

Upstream product

• 1313043-31-0 2,2,2-trifluoro-1-(1-(2-methoxyethyl)-4-(trifluoromethyl)-1H-indol-3-yl)ethanone 
• 1313043-30-9 1-(2-methoxyethyl)-4-(trifluoromethyl)-1H-indole 
• 1208977-19-8 2,2,2-trifluoro-N-(4-fluoro-3-pyridin-4-yl-benzyl)-acetamide hydrochloride 
• 1067427-53-5 2,2,2-trifluoro-N-(4-fluoro-3-piperidin-4-yl-benzyl)acetamide hydrochloride 
• 1313043-32-1 1-(2-methoxyethyl)-4-(trifluoromethyl)-1H-indole-3-carboxylic acid 
• 128562-95-8 4-(trifluoromethyl)-1H-indole 
• 202865-68-7 3-bromo-4-fluoro-benzylamine hydrochloride 
• 1692-15-5 4-pyridylboronic acid 

Downstream Products

• 1313040-69-5 [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indol-3-yl]-methanone hydrochloride 

Relevant academic research and scientific papers

INDOLYL-PIPERIDINYL BENZYLAMINES AS BETA-TRYPTASE INHIBITORS

The present invention discloses and claims a series of substituted indolyl-piperidinyl benzylamines of formula (I), wherein R1, R2 and R3 are as described herein. More specifically, the compounds of this invention are inhibitors of β-tryptase and are, therefore, useful as pharmaceutical agents. Additionally, this invention also discloses methods of preparation of substituted indolyl-piperidinyl benzylamines. In one of the embodiments, there is provided the compounds of formula (I) wherein R3 is (II).