1285620-97-4

Upstream product

• 480-91-1 oxisoindole 
• 136918-14-4 phthalimide 
• 22813-66-7 3-chloro-2H-isoindole-1-carboxaldehyde 
• 108-98-5 thiophenol 
• 22813-67-8 3-bromo-2H-isoindole-1-carboxaldehyde 
• 22813-65-6 1-(3-bromo-1H-isoindole-1-ylidene)-N,N-dimethylmethylamine 

Relevant academic research and scientific papers

Nucleophilic substitutions in the isoindole series as a valuable tool to synthesize derivatives with antitumor activity

A novel synthetic approach to the synthesis of 3-substituted isoindoles through nucleophilic substitution of 3-halo derivatives by charged carbon, and neutral nitrogen, oxygen, and sulfur nucleophiles, assisted by a 1-acyl group, is reported. Aryl-thio-isoindoles, obtained through a direct nucleophilic substitution with sulfur nucleophiles, showed cytotoxic activity, with GI 50 values from micromolar to sub-micromolar concentrations, against the total number of cell lines investigated.