480-91-1Relevant articles and documents
The ninhydrin core as carbonyl source to access 2-(2′-hydroxyaryl)benzimidazoles exploiting the ortho selectivity of ninhydrin-phenol adducts
Das, Suven,Maity, Suvendu,Ghosh, Prasanta,Dutta, Arpita
, p. 2862 - 2872 (2021/08/13)
Although ninhydrin is an essential analytical tool in biochemical and forensic sciences, for the past several years, it has been employed as efficient building block for diverse organic scaffolds. In the present work, the ortho selectivity of ninhydrin-phenol adducts has been exploited to obtain 2-(2′-hydroxyaryl)benzimidazoles which are well known excited state intramolecular proton transfer (ESIPT) fluorophores. Under acidic condition, 3-(2-hydroxyaroyl)isoindolin-1-one intermediate generated in situ from ninhydrin-phenol adducts was treated with o-phenylenediamine resulting benzimidazole scaffolds via a two-step one pot strategy.
Construction of a turn-on probe for fast detection of H2S in living cells based on a novel H2S trap group with an electron rich dye
Yang, Qian,Zhan, Fuxu,Wang, Qiufen,Zhuang, Zhiyuan,Zhang, Guangyou,Zheng, Gengxiu
, p. 106156 - 106160 (2015/12/26)
A turn-on probe (ANR) for fast detection of H2S is constructed based on a 2-(azidomethyl)-4-nitrobenzoate moiety as a trap group. This group is very effective for the design of H2S probes especially with electron rich dyes. The potential biological applications of ANR were proved by employing it for fluorescence imaging of H2S in living cells.
Reaction of 1-ethoxyisoindole with maleimide and its derivatives
Levkov, Igor V.,Cassel, Stephanie,Voitenko, Zoia V.,Palamarchuk, Gennady V.,Shishkin, Oleg V.,Shishkina, Svetlana V.,Lattes, Armand,Rico-Lattes, Isabelle
experimental part, p. 1671 - 1681 (2012/09/11)
We have reported1 the possibility of conducting the Diels-Alder [4+2]-cycloaddition reaction with isoindoles that exist predominantly in the isoindoline form, due to the Curtin-Hammet principle. Pursuing our research, we used 1-ethoxyisoindole as the most evident analog of 1-aminoisoindole. This compound is a typical simple isoindole existing chiefly as the isoindoline tautomer. We have studied the reactions of 1-ethoxyisoindoles with maleimide and its derivatives as active dienophiles. In addition, this paper describes the synthesis of a novel compound - tri-(2-methoxycarbonyl)benzylamine.
