128569-20-0 Usage
Uses
Used in Agricultural Pesticides:
Methyl 2-(N-(4-chloro-6-methoxypyrimidin-2-ylcarbamoyl)sulfamoyl)benzoate is utilized as an active ingredient in agricultural pesticides for its ability to control a wide range of pests. It is particularly effective in protecting crops from damage caused by insects, mites, and nematodes, ensuring the health and productivity of various agricultural plants.
Used in Crop Protection:
In the agricultural industry, methyl 2-(N-(4-chloro-6-methoxypyrimidin-2-ylcarbamoyl)sulfamoyl)benzoate serves as a crucial component in crop protection strategies. It is applied to safeguard a variety of crops from potential harm inflicted by pests, thereby maintaining crop yields and quality. Its low toxicity profile further ensures the safety of the environment and human health in agricultural settings.
Check Digit Verification of cas no
The CAS Registry Mumber 128569-20-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,5,6 and 9 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 128569-20:
(8*1)+(7*2)+(6*8)+(5*5)+(4*6)+(3*9)+(2*2)+(1*0)=150
150 % 10 = 0
So 128569-20-0 is a valid CAS Registry Number.
InChI:InChI=1/C14H13ClN4O6S/c1-24-11-7-10(15)16-13(17-11)18-14(21)19-26(22,23)9-6-4-3-5-8(9)12(20)25-2/h3-7H,1-2H3,(H2,16,17,18,19,21)
128569-20-0Relevant articles and documents
Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase
Lee, Yu-Ting,Cui, Chang-Jun,Chow, Eve W. L.,Pue, Nason,Lonhienne, Thierry,Wang, Jian-Guo,Fraser, James A.,Guddat, Luke W.
, p. 210 - 219 (2013/02/23)
The sulfonylurea herbicides exert their activity by inhibiting plant acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthesis pathway. It has previously been shown that if the gene for AHAS is deleted in Candida albicans, attenuation of virulence is achieved, suggesting AHAS as an antifungal drug target. Herein, we have cloned, expressed, and purified C. albicans AHAS and shown that several sulfonylureas are inhibitors of this enzyme and possess antifungal activity. The most potent of these compounds is ethyl 2-(N-((4-iodo-6-methoxypyrimidin-2-yl)carbamoyl) sulfamoyl)benzoate (10c), which has a Ki value of 3.8 nM for C. albicans AHAS and an MIC90 of 0.7 μg/mL for this fungus in cell-based assays. For the sulfonylureas tested there was a strong correlation between inhibitory activity toward C. albicans AHAS and fungicidal activity, supporting the hypothesis that AHAS is the target for their inhibitory activity within the cell.
