1285696-25-4Relevant academic research and scientific papers
Asymmetric synthesis of α-alkenyl homoallylic primary amines via 1,2-addition of Grignard reagent to α,β-unsaturated phosphonyl imines
Xiong, Yiwen,Mei, Haibo,Xie, Chen,Han, Jianlin,Li, Guigen,Pan, Yi
, p. 15820 - 15826 (2013)
A series of chiral N-phosphonyl protected α-alkenyl homoallylic primary amines were synthesized by asymmetric addition of allylmagnesium bromide to chiral α,β-unsaturated imines. Only the 1,2-adduct was obtained for all the imines with good yields and excellent diastereoselectivities. The chiral auxiliary could be easily removed under simple conditions, giving free multiple functionalized primary amines.
Direct catalytic asymmetric aminoallylation of aldehydes: Synergism of chiral and nonchiral Bronsted acids
Ren, Hong,Wulff, William D.
supporting information; experimental part, p. 5656 - 5659 (2011/06/18)
The development of a catalytic asymmetric method for the direct aminoallylation of aldehydes is described that gives high asymmetric inductions for a broad range of substrates including both aromatic and aliphatic aldehydes. This method allows for direct isolation of unprotected analytically pure homoallylic amines without chromatography. The unique catalyst system developed for this process involves the synergistic interaction between a chiral and a nonchiral Bronsted acid.
