128574-68-5

Upstream product

• 151255-01-5 (2E)-5-<(4S,5R)-4-Ethyl-2,2,5-trimethyl-1,3-dioxolan-4-yl>-1-(4-methoxyphenyl)-pent-2-en-1-one 
• 151254-94-3 3-O-Benzyl-5-deoxy-3-C-ethyl-1,2-O-(1-methylethylidene)-α-D-ribofuranose 
• 151255-03-7 (4S,5R)-4,5-Di-tert-butyldimethylsilyloxy-5-ethylhexanal 
• 151254-95-4 3-O-Benzyl-5-deoxy-3-C-ethyl-α-D-ribofuranose 
• 151378-19-7 3-<(4S,5R)-4-Ethyl-2,2,5-trimethyl-1,3-dioxolan-4-yl>propanal 
• 151254-98-7 (4S,5R)-4,5-Dihydroxy-4-ethylhexanoic acid 1,4-lactone 
• 151255-00-4 3-<(4S,5R)-4-Ethyl-2,2,5-trimethyl-1,3-dioxolan-4-yl>propanol 
• 128574-69-6 (2S,5S)-2-Ethyl-2-<(1R)-1-hydroxyethyl>-5-<(1E)-2-(4-methoxyphenyl)ethenyl>tetrahydrofuran 
• 106286-24-2 (E)-5-((4R,5R)-4-Ethyl-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-1-(4-methoxy-phenyl)-pent-1-en-3-ol 
• 106286-23-1 (E)-5-((4R,5R)-4-Ethyl-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-1-(4-methoxy-phenyl)-pent-2-en-1-ol 

Downstream Products

• 128531-41-9 (2S,5R)-2-<(1R)-1-Benzyloxymethoxyethyl>-2-ethyl-5-formyltetrahydrofuran 
• 106313-34-2 (2R,3S,6R)-3-Ethyl-6-[(E)-2-(4-methoxy-phenyl)-vinyl]-2-methyl-tetrahydro-pyran-3-ol 

Relevant academic research and scientific papers

Stereoselective Total Synthesis of Polyether Ionophore Antibiotics, Isolasalocid A and Lasalocid A. Part 1. Stereocontrolled Construction of the C Rings (C18-C24) by Acid-Catalyzed Cyclization of p-Methoxyphenylallyl Alcohols

The C18-C24 subunits (11, 12) of isolasalocid A (9) and lasalocid A (10) were synthesized stereoselectively via construction of the tetrahydrofuran and tetrahydropyran rings by acid-catalyzed cyclization of the corresponding p-methoxyphenylallyl alcohols (18, 25). Key words: polyether antibiotic; total synthesis; stereoselective synthesis; tetrahydrofuran; tetrahydropyran; acid-catalyzed cyclization.

SYNTHESIS OF SUBSTITUTED TETRAHYDROFURANS AND TETRAHYDROPYRANS. 2. STEREOCONTROLLED ACID-CATALYZED CYCLIZATIONS

A new acid-catalyzed synthesis of thermodinamically stable 2,5-substituted tetrahydrofurans and 2,6-substituted tetrahydropyrans was developed in order to apply to the synthesis of complex polyether antibiotics.