128587-94-0Relevant academic research and scientific papers
HECK REACTIONS IN SOLID PHASE SYNTHESIS
Yu, Kuo-Long,Deshpande, Milind S.,Vyas, Dolatrai M.
, p. 8919 - 8922 (1994)
Heck reactions of polymer bound aryl iodide (1) or styrene (2) with olefins or aryl halides generally gave good yields of products of high purity.The methodology developed can be applied as a convenient procedure for generating 1,2-disubstituted olefins i
One-pot Suzuki-Heck relay to prepare industrially valuable intermediates using the Pd-Cy?Phine catalyst system
Das, Uttam K.,Clément, Roxanne,Johannes, Charles W.,Robins, Edward G.,Jong, Howard,Baker, R. Tom
, p. 4599 - 4603 (2017/10/19)
A rare example of a one-pot, palladium-catalyzed Suzuki-Heck sequence has been developed with applicability to APIs and organoelectronic materials. High throughput screening was used to expedite development and survey strategies. Interchangeability of the coupling partners and the avoidance of intermediate isolation gives operational flexibility, which can be used to improve process efficiency and suppress by-product formation.
Chemoselective and Sequential Palladium-Catalyzed Couplings for the Generation of Stilbene Libraries via Immobilized Substrates
Traficante, Carla I.,Fagundez, Catherine,Serra, Gloria L.,Mata, Ernesto G.,Delpiccolo, Carina M. L.
supporting information, p. 225 - 229 (2016/06/01)
A versatile palladium-catalyzed tandem synthetic sequence to afford E-stilbenes libraries has been developed. Excellent regio- and stereocontrol have been achieved by means of the sequence of Hiyama and Heck cross-couplings. Undesirable homocoupling bypro
Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups
Anthony, Nahoum G.,Breen, David,Clarke, Joanna,Donoghue, Gavin,Drummond, Allan J.,Ellis, Elizabeth M.,Gemmell, Curtis G.,Helesbeux, Jean-Jacques,Hunter, Iain S.,Khalaf, Abedawn I.,Mackay, Simon P.,Parkinson, John A.,Suckling, Colin J.,Waigh, Roger D.
, p. 6116 - 6125 (2008/09/16)
The synthesis and properties of 80 short minor groove binders related to distamycin and the thiazotropsins are described. The design of the compounds was principally predicated upon increased affinity arising from hydrophobic interactions between minor groove binders and DNA. The introduction of hydrophobic aromatic head groups, including quinolyl and benzoyl derivatives, and of alkenes as linkers led to several strongly active antibacterial compounds with MIC for Staphylococcus aureus, both methicillin-sensitive and -resistant strains, in the range of 0.1-5 μg mL-1, which is comparable to many established antibacterial agents. Antifungal activity was also found in the range of 20-50 μg mL-1 MIC against Aspergillus niger and Candida albicans, again comparable with established antifungal drugs. A quinoline derivative was found to protect mice against S. aureus infection for a period of up to six days after a single intraperitoneal dose of 40 mg kg-1.
Hypoglycemic stilbazolte derivatives
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, (2008/06/13)
Stilbazole derivatives in which the phenyl ring is substituted with a carboxylic acid group at the para position or a group convertible in the body to a carboxylic acid group, are useful as hypoglycemic agents.
