128592-65-4Relevant academic research and scientific papers
Metal-Free C-N or C-C Bond Cleavages of α-Azido Ketones: An Oxidative-Amidation Strategy for the Synthesis of α-Ketothioamides and Amides
Yu, Pei,Wang, Yuwei,Zeng, Zhigang,Chen, Yunfeng
, p. 14883 - 14891 (2019/11/11)
A novel metal-free oxidative-amidation strategy for the synthesis of α-ketothioamides and amides from α-azido ketones was developed. The C-H bond thionation of α-azido ketones with elemental sulfur could form α-ketothioacyl azide, which was then nucleophilically attacked by amines, causing the cleavage of the C-N bond to afford α-ketothioamides, while amides could be formed with the release of nitrogen gas and cyano anion in the presence of PhI(OAc)2 by selective C-C bond cleavage.
Reactions of diphenacylaniline and diphenacyl sulfide under Gewald conditions: Generation of enamines and thioamides
Paul, Nidhin,Sathishkumar, Ramalingam,Anuba, Chellathurai,Muthusubramanian, Shanmugam
, p. 7445 - 7451 (2013/06/27)
The 1,5-diketone, diphenacylaniline, yielded an enamine under Gewald conditions, while another 1,5-diketone, diphenacyl sulfide, resulted in thioamide formation under identical conditions. 2-Amino-4-(3-oxo-1,3- diphenylpropyl)-4,5,6,7-tetrahydrobenzo[b]th
Iron-catalysed Oxidation of N,N-(Dialkyl)acylmethylamines with Molecular Oxygen in the Presence of either 2-Mercaptoethanol or Sodium Sulphide
Murata, Satoru,Suzuki, Kaoru,Miura, Masahiro,Nomura, Masakatsu
, p. 361 - 365 (2007/10/02)
Air-oxidation of N,N-(dialkyl)acylmethylamines (1a-f) using a catalytic amount of 2O> in the presence of 2-mercaptoethanol gave the corresponding α-oxo amides (2a-f) in moderate to good yields.With sodium sulphide in place of the thiol α-oxo thioamides (9a-f) were obtained as the predominant products.
