23080-22-0

Usage

Type of compound

Ketone

Groups present

Tolyl group, Ethylsulfanyl group

Uses

Pharmaceutical intermediate, Agrochemical intermediate, Material science research

Structure

Carbonyl group, Sulfur atom bonded to an ethyl group

Value

Building block for the synthesis of other organic compounds and materials

Properties and potential uses

Vary depending on specific conditions and applications

Upstream product

• 98475-04-8 1-(4-methylphenyl)-2-(p-tolylsulfonyloxy)ethanone 
• 122-00-9 para-methylacetophenone 
• 108-88-3 toluene 
• 619-41-0 4-(bromoacetyl)toluene 
• 4209-24-9 p-methylphenacyl chloride 

Downstream Products

• 69626-08-0 3,8-di-p-tolyl-2,5,6,7-tetrahydro-[1,4,7]thiadiazonine 
• 71764-43-7 1,2,3,4,9,9a-hexahydro-6,9a-di(p-methylphenyl)pyrimido<2,1-c><1,4>thiazine 
• 74794-44-8 (3-phenylthiene-2,5-diyl)bis[(4-tolyl)methanone] 
• 100990-22-5 (3R,4S)-3,4-Di-p-tolyl-tetrahydro-thiophene-3,4-diol 
• 100989-99-9 3,4-Di-p-tolyl-2,5-dihydro-thiophene 
• 138711-19-0 2-(2-Oxo-2-p-tolyl-ethanesulfinyl)-1-p-tolyl-ethanone 
• 92802-28-3 2,6-Di-p-tolyl-[1,4]dithiine 
• 74794-41-5 [3,4-Dimethyl-5-(4-methyl-benzoyl)-thiophen-2-yl]-p-tolyl-methanone 
• 74794-43-7 [5-(4-Methyl-benzoyl)-3,4-diphenyl-thiophen-2-yl]-p-tolyl-methanone 
• 84258-86-6 3-chloro-6-methylbenzothiophene-2-carboxaldehyde 
• 1349772-30-0 di[6-chloro-2-(4-methylphenyl)-4-phenyl-3-quinolyl] sulfide 
• 1349772-16-2 di[2-(4-methylphenyl)-4-phenyl-3-quinolyl] sulfide 
• 1393811-87-4 cis-2,6-di(4-methylphenyl)-1,4-oxathiane 
• 220102-36-3 1-(4-methylphenyl)-2-morpholino-2-thioxo-1-ethanone 

Relevant academic research and scientific papers

Synthesis of Thioethers Using Triethylamine-Activated Phosphorus Decasulfide (P410

The synthesis of thioethers in excellent yields was achieved under mild conditions via the displacement reaction of halogens by sulfur. The cross-reaction of 2-(α-bromoacetyl)thiophene with triethylamine-activated phosphorus decasulfide (Et3N-P2S5) was elaborated by utilizing DFT calculations.

Thiophene synthesis via 1,1-carboboration

Reaction of bis(tert-butylethynyl)sulfide with the boron Lewis acid reagents X-B(C6F5)2 (X = CH3, Cl, C6F5) in pentane at r.t. gave the respective borylated thiophenes in a sequence of 1,1-

Stereoselective synthesis of cis-2,6-disubstituted morpholines and 1,4-oxathianes by intramolecular reductive etherification of 1,5-diketones

A simple and efficient, Lewis acid catalysed reductive etherification strategy for the stereoselective synthesis of cis-2,6- disubstituted morpholines and 1,4-oxathianes starting from readily available 1,5-diketones has been developed. The strategy is used in the total synthesis of morpholine-based natural products (±)-chelonin A and formal total synthesis of (±)-chelonin C.

One-pot preparation of arylethynyl sulfides and bis(arylethynyl) sulfides

An efficient preparation for arylethynyl sulfides 1 and bis(arylethynyl) sulfides 2 has been accomplished through a one-pot, three-step strategy that starts from arylethanonyl sulfides and bis(arylethanonyl) sulfides, respectively, without the use of various terminal arylacetylenes as substrates. When lithium hexamethyldisilazane (LHMDS), ClP(O)(OEt)2, and LHMDS were sequentially added to a tetrahydrofuran solution of different substrates [arylethanonyl sulfides or bis(arylethanonyl) sulfides], 1 or 2 were obtained in moderate to good yields. The reaction procedure involves the formation of an enol phosphate and a subsequent base-induced elimination. An efficient preparation of arylethynyl sulfides 1 and bis(arylethynyl) sulfides 2 has been accomplished by a one-pot, three-step strategy that starts from arylethanonyl sulfides and bis(arylethanonyl) sulfides, respectively, to give 1 and 2 in moderate to good yields. The reaction mechanism involves the formation of an enol phosphate that undergoes a subsequent base-induced elimination. Copyright

An aquatic pseudo-four-component reaction for the synthesis of highly substituted thiophenes

A novel and simple procedure was developed for the construction of fully substituted thiophenes. A series of α-haloacetophenone derivatives were converted into fully substituted thiophenes by treatment with sodium sulfide in the presence of 1,8-diazabicyc

Synthesis of oxathiane and morpholine from acyclic precursors: A modified Mitsunobu reaction

Synthesis of a set of isomeric 2,4,6-triarylmorpholines and 2,6-diaryloxathianes from the corresponding 1,5-diols has been described. The method provides an efficient route to six-membered heterocycles from acyclic diols and is found to be better than Mitsunobu procedure in yield and waste management. In a related study, the ring contraction of pyranone to two isomeric cyclopentenone derivatives through Nazarov reaction has been noticed.

Synthesis of novel N-hydroxy heterocycles via intramolecular reductive cyclization of diketoximes by NaBH3CN

A simple and efficient protocol for the construction of substituted piperazines, piperidines, thiomorpholines, decahydroquinolines, perhydrocyclopenta[b]pyridine, and pyrrolidines bearing N-hydroxy substituents through intramolecular reductive cyclization of diketoximes using sodium cyanoborohydride is described.

Convenient synthesis of symmetrical diketosulfides from enolizable ketones using [hydroxy(tosyloxy)iodo]benzene and Na2S·9H20

An efficient method for the preparation of symmetrical diketosulfides of the type ArCOCH2SCH2COAr has been developed from the reaction of [hydroxy(tosyloxy)iodo]benzene with various acetophenones, followed by treatment with Na2

A new class of sulfur-linked bis-1,2,3-selenadiazoles, 1,2,3-thiadiazoles, and 2H-diazaphospholes

Novel sulfur-linked bis-heterocycles, bis-1,2,3-selenadiazoles 4, 1,2,3-thiadiazoles 5, and 2H-diazaphospholes 1, were synthesized from bis(2-oxo-2-phenylethanone)sulfide 2 by adopting a simple and well-versed methodology.

One-pot oxidation and bromination of 3,4-diaryl-2,5-dihydrothiophenes using Br2: Synthesis and application of 3,4-diaryl-2,5-dibromothiophenes

(Chemical Equation Presented) A class of 3,4-diaryl-2,5-dibromothiophenes (1b-5b) was synthesized by a one-pot reaction of 3,4-diaryl-2,5- dihydrothiophenes with Br2 reagent in excellent yield (83-92%). It was found that Br2 performed a double function (oxidation and bromination) during the conversion of 3,4-diaryl-2,5-dihydrothiophenes to 3,4-diaryl-2,5-dibromothiophenes. The application of 3,4-diaryl-2,5- dibromothiophenes used as building blocks was also investigated. Employing 3,4-diphenyl-2,5-dibromothiophene (1b) as a template, a class of 2,3,4,5-tetraarylthiophenes was prepared by the Suzuki coupling reaction. This provided a new and simple approach to the preparation of 2,3,4,5- tetraarylthiophenes.