128592-67-6Relevant academic research and scientific papers
A study of the Willgerodt-Kindler reaction to obtain thioamides and α-ketothioamides under solvent-less conditions
Valdez-Rojas, Jose Ernesto,Rios-Guerra, Hulme,Ramirez-Sanchez, Alma Leticia,Garcia-Gonzalez, Guadalupe,Alvarez-Toledano, Cecilio,Lopez-Cortes, Jose Guadalupe,Toscano, Ruben A.,Penieres-Carrillo, Jose Guillermo
supporting information; experimental part, p. 567 - 573 (2012/08/08)
In this paper, the results obtained in the synthesis of thioamides and α-ketothioamides by a modification of the Willgerodt-Kindler reaction, under solvent-free and noncatalyst conditions using IR energy as a source of activation, are presented. The use of IR energy in these reactions has been shown to lead to a mixture of thioamide and α-ketothioamide as the main products in most cases, with the latter predominating. The yields of α-ketothioamides from most of these reactions are better than those reported previously. To the best of our knowledge, this is the first time that IR energy has been applied to promote the Willgerodt-Kindler reaction.
Iron-catalysed Oxidation of N,N-(Dialkyl)acylmethylamines with Molecular Oxygen in the Presence of either 2-Mercaptoethanol or Sodium Sulphide
Murata, Satoru,Suzuki, Kaoru,Miura, Masahiro,Nomura, Masakatsu
, p. 361 - 365 (2007/10/02)
Air-oxidation of N,N-(dialkyl)acylmethylamines (1a-f) using a catalytic amount of 2O> in the presence of 2-mercaptoethanol gave the corresponding α-oxo amides (2a-f) in moderate to good yields.With sodium sulphide in place of the thiol α-oxo thioamides (9a-f) were obtained as the predominant products.
