128595-72-2

Basic information

• Product Name: (S)-methyl 2-(benzyloxycarbonylamino)-3-(3,4-dimethoxyphenyl)propanoate
• Synonyms: (S)-methyl 2-(benzyloxycarbonylamino)-3-(3,4-dimethoxyphenyl)propanoate
• CAS NO: 128595-72-2
• Molecular Weight: 373.406
• Mol File: 128595-72-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-methyl 2-(benzyloxycarbonylamino)-3-(3,4-dimethoxyphenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-methyl 2-(benzyloxycarbonylamino)-3-(3,4-dimethoxyphenyl)propanoate(128595-72-2)
• EPA Substance Registry System: (S)-methyl 2-(benzyloxycarbonylamino)-3-(3,4-dimethoxyphenyl)propanoate(128595-72-2)

Safety Data

• Hazardous Substances Data: 128595-72-2(Hazardous Substances Data)

Upstream product

• 73404-23-6 N-benzyloxycarbonyl-3,4-dimethoxy-L-phenylalanine 
• 74-88-4 methyl iodide 

Downstream Products

• 1173933-75-9 [(1S,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol 
• 78083-80-4 (S)-2-amino-3-(3,4-dimethoxyphenyl)propionic acid methyl ester 
• 161156-54-3 (-)-N-benzyloxycarbonyl-2-nitro-3,4-dihydroxyphenylalanine methyl ester 

Relevant articles and documents

Anticancer activity of ruthenium(II) arene complexes bearing 1,2,3,4-tetrahydroisoquinoline amino alcohol ligands

Ruthenium complexes offer potential reduced toxicity compared to current platinum anticancer drugs. 1,2,3,4-tetrahydrisoquinoline amino alcohol ligands were synthesised, characterised and coordinated to an organometallic Ru(II) centre. These complexes were evaluated for activity against the cancer cell lines MCF-7, A549 and MDA-MB-231 as well as for toxicity in the normal cell line MDBK. They were observed to be moderately active against only the MCF-7 cells with the best IC50 value of 34 μM for the cis-dia-stereomeric complex C4. They also displayed excellent selectivity by being relatively inactive against the normal MDBK cell line with SI values ranging from 2.3 to 7.4.